A-800141, also known by its CAS number 681245-85-2, is a chemical compound that belongs to a class of substances known for their potential pharmacological applications. While specific details about A-800141 may not be widely available, compounds in this category often exhibit properties that make them of interest in medicinal chemistry, particularly in the context of neurological or psychiatric disorders. Typically, such compounds may interact with various neurotransmitter systems, potentially influencing mood, cognition, or behavior. The structure of A-800141 likely includes functional groups that facilitate its interaction with biological targets, which could include receptors or enzymes. As with many experimental compounds, the safety profile, efficacy, and mechanism of action would require thorough investigation through preclinical and clinical studies to establish its potential therapeutic uses. Researchers often explore these compounds in the context of drug development, aiming to understand their pharmacodynamics and pharmacokinetics.

A-800141

(A800141)

681245-85-2: A-800141, also known by its CAS number 681245-85-2, is a chemical compound that belongs to a class of substances known for their potential pharmacological applications. While specific details about A-800141 may not be widely available, compounds in this category often exhibit properties that make them of interest in medicinal chemistry, particularly in the context of neurological or psychiatric disorders. Typically, such compounds may interact with various neurotransmitter systems, potentially influencing mood, cognition, or behavior. The structure of A-800141 likely includes functional groups that facilitate its interaction with biological targets, which could include receptors or enzymes. As with many experimental compounds, the safety profile, efficacy, and mechanism of action would require thorough investigation through preclinical and clinical studies to establish its potential therapeutic uses. Researchers often explore these compounds in the context of drug development, aiming to understand their pharmacodynamics and pharmacokinetics.

<p>A-800141 is an orally active and selective MetAP2 inhibitor with an IC50 of 12 nM, while showing weaker inhibitory activity against MetAP1 (IC50: 36 μM). GAPDH can serve as a biomarker for monitoring the inhibition of MetAP2 by A-800141. This compound exhibits anti-angiogenic and anticancer properties in various xenograft tumor models.</p>

CAS 681245-85-2

A-800141 (A800141)

A-800141

Ref: TM-T204983