CAS 681492-22-8
:Delamanid
Description:
Delamanid is an anti-tuberculosis medication primarily used in the treatment of multidrug-resistant tuberculosis (MDR-TB). It is classified as a nitro-dihydro-imidazooxazole derivative and functions by inhibiting the synthesis of mycolic acids, essential components of the bacterial cell wall in Mycobacterium tuberculosis. This mechanism disrupts the integrity of the bacterial cell wall, leading to cell death. Delamanid is typically administered orally and is known for its relatively favorable pharmacokinetic profile, including good absorption and metabolism. The drug is often used in combination with other anti-TB agents to enhance efficacy and reduce the risk of resistance development. Common side effects may include headache, nausea, and potential cardiovascular effects, necessitating monitoring during treatment. Delamanid's introduction has been significant in addressing the challenges posed by drug-resistant TB strains, contributing to global health efforts aimed at controlling and eliminating tuberculosis.
Formula:C25H25F3N4O6
InChI:InChI=1S/C25H25F3N4O6/c1-24(15-31-14-22(32(33)34)29-23(31)38-24)16-35-18-4-2-17(3-5-18)30-12-10-20(11-13-30)36-19-6-8-21(9-7-19)37-25(26,27)28/h2-9,14,20H,10-13,15-16H2,1H3/t24-/m1/s1
InChI key:InChIKey=XDAOLTSRNUSPPH-XMMPIXPASA-N
SMILES:C(OC1=CC=C(C=C1)N2CCC(OC3=CC=C(OC(F)(F)F)C=C3)CC2)[C@@]4(C)CN5C(O4)=NC(N(=O)=O)=C5
Synonyms:- (2R)-2,3-Dihydro-2-methyl-6-nitro-2-[[4-[4-[4-(trifluoromethoxy)phenoxy]-1-piperidinyl]phenoxy]methyl]imidazo[2,1-b]oxazole
- Delamanid
- Deltyba
- Imidazo[2,1-b]oxazole, 2,3-dihydro-2-methyl-6-nitro-2-[[4-[4-[4-(trifluoromethoxy)phenoxy]-1-piperidinyl]phenoxy]methyl]-, (2R)-
- Opc 67683
- Unii-8Oot6M1Pc7
- (2R)-2-Methyl-6-nitro-2-[[4-[4-[4-(trifluoromethoxy)phenoxy]piperidin-1-yl]phenoxy]methyl]-3H-imidazo[2,1-b][1,3]oxazole
- DelaManid(OPC-67683)
- DELAMANID;OPC67683;OPC 67683
- CS-2255
- (R)-2-Methyl-6-nitro-2-((4-(4-(4-(trifluoromethoxy)phenoxy)piperidin-1-yl)phenoxy)methyl)-2,3-dihydroimidazo[2,1-b]oxazole
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Found 9 products.
(R)-2-METHYL-6-NITRO-2-((4-(4-(4-(TRIFLUOROMETHOXY)PHENOXY)PIPERIDIN-1-YL)PHENOXY)METHYL)-2,3-DIHYDROIMIDAZO[2,1-B]OXAZOLE
CAS:Purity:95%Molecular weight:534.492004394531Delamanid
CAS:Formula:C25H25F3N4O6Purity:>98.0%(HPLC)Color and Shape:White to Light yellow powder to crystalMolecular weight:534.49Delamanid
CAS:<p>Delamanid (OPC-67683), a nitro-dihydro-imidazooxazole, is an anti-TB drug that blocks mycolic acid synthesis in bacterial walls.</p>Formula:C25H25F3N4O6Purity:99.89% - >99.99%Color and Shape:SolidMolecular weight:534.48Delamanid
CAS:<p>Stability Hygroscopic<br>Applications Delamanid is a novel anti-tuberculosis medication that inhibits mycolic acid synthesis and shows potent in vitro and in vivo activity against drug-resistant strains of Mycobacterium tuberculosis.<br>References Gler, M.T., et al.: New Engl. J. Med., 366, 2151 (2012); Skripconoka, V., et al.: Eur. Respir. J., 41, 1393 (2012); Diacon, A.H., et al.: Int. J. Tuberc. Lung D., 15, 949 (2011); Zhang, Q., et al.: Cell Biochem. Biophys., 67, 957 (2013)<br></p>Formula:C25H25F3N4O6Color and Shape:NeatMolecular weight:534.48Delamanid
CAS:<p>Delamanid is a second-line antimicrobial agent, which is a synthetic derivative of the nitro-dihydro-imidazooxazole compound. Delamanid originates from a laboratory synthesis designed to target and inhibit specific components of bacterial cell wall synthesis. The mode of action involves the inhibition of mycolic acid synthesis, which is critical for the maintenance and construction of the cell wall in Mycobacterium tuberculosis. This inhibition disrupts bacterial cell wall integrity, ultimately exerting a bactericidal effect against actively replicating and dormant mycobacterial cells.</p>Formula:C25H25F3N4O6Purity:Min. 98 Area-%Color and Shape:PowderMolecular weight:534.48 g/mol
