2-Fluoro-3',5'-bis-O-(hydroxyphosphinato)adenosine is a modified nucleoside derivative of adenosine, characterized by the presence of a fluorine atom at the 2-position of the ribose sugar and two hydroxyphosphinato groups at the 3' and 5' positions. This compound exhibits unique biochemical properties due to the modifications, which can influence its interaction with enzymes and nucleic acid structures. The hydroxyphosphinato groups can enhance the stability and bioactivity of the molecule, potentially making it a useful tool in biochemical research or therapeutic applications. The fluorine substitution may also affect the compound's polarity and solubility, impacting its cellular uptake and overall biological activity. As a nucleoside analog, it may serve as a substrate or inhibitor for various enzymes involved in nucleic acid metabolism. Overall, 2-fluoro-3',5'-bis-O-(hydroxyphosphinato)adenosine represents a significant modification of adenosine that could have implications in medicinal chemistry and molecular biology.

2-fluoro-3',5'-bis-O-(hydroxyphosphinato)adenosine

68245-92-1: 2-Fluoro-3',5'-bis-O-(hydroxyphosphinato)adenosine is a modified nucleoside derivative of adenosine, characterized by the presence of a fluorine atom at the 2-position of the ribose sugar and two hydroxyphosphinato groups at the 3' and 5' positions. This compound exhibits unique biochemical properties due to the modifications, which can influence its interaction with enzymes and nucleic acid structures. The hydroxyphosphinato groups can enhance the stability and bioactivity of the molecule, potentially making it a useful tool in biochemical research or therapeutic applications. The fluorine substitution may also affect the compound's polarity and solubility, impacting its cellular uptake and overall biological activity. As a nucleoside analog, it may serve as a substrate or inhibitor for various enzymes involved in nucleic acid metabolism. Overall, 2-fluoro-3',5'-bis-O-(hydroxyphosphinato)adenosine represents a significant modification of adenosine that could have implications in medicinal chemistry and molecular biology.

<p>Poly(2'-Fluoro-2'-Deoxyadenylic Acid) (PFDAA) is a synthetic analog of natural RNA polymerase II α subunit. It has been shown to be a potent inhibitor of protein synthesis in vitro, with an IC50 of 1 μM. PFDAA has been used as a primer in PCR reactions and as a template for transcription reactions. In these reactions, PFDAA was able to phosphorylate the β-subunit of RNA polymerase II and to induce transcriptase activity, but not DNA replication. The divalent cation requirement for this reaction may be due to the formation of a ternary complex with the template strand and ATP.</p>

CAS 68245-92-1

2-fluoro-3',5'-bis-O-(hydroxyphosphinato)adenosine

Poly(2'-Fluoro-2'-Deoxyadenylic Acid)

Ref: 3D-TP83535