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CAS 68278-23-9

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Eflornithine hydrochloride

Description:
Eflornithine hydrochloride is a pharmaceutical compound primarily used in the treatment of African sleeping sickness, specifically the second stage caused by Trypanosoma brucei gambiense. It is a reversible inhibitor of ornithine decarboxylase, an enzyme crucial for polyamine synthesis, which is essential for cell growth and differentiation. The substance appears as a white to off-white crystalline powder and is soluble in water, making it suitable for intravenous administration. Eflornithine hydrochloride is characterized by its relatively low toxicity profile, which allows for its use in patients with limited treatment options. The compound is typically administered in a clinical setting under strict medical supervision due to potential side effects, including gastrointestinal disturbances and hematological changes. Its mechanism of action and specificity for the target enzyme make it a valuable therapeutic agent in combating this neglected tropical disease. Overall, Eflornithine hydrochloride represents a significant advancement in the treatment of a serious parasitic infection, highlighting the importance of targeted drug development in addressing global health challenges.
Formula:C6H12F2N2O2·ClH
InChI:InChI=1S/C6H12F2N2O2.ClH/c7-4(8)6(10,5(11)12)2-1-3-9;/h4H,1-3,9-10H2,(H,11,12);1H
InChI key:InChIKey=VKDGNNYJFSHYKD-UHFFFAOYSA-N
SMILES:C(CCCN)(C(F)F)(C(O)=O)N.Cl
Synonyms:
  • 2,5-Diamino-2-(difluoromethyl)pentanoic acid hydrochloride
  • 2-(Difluoromethyl)-DL-ornithine monohydrochloride
  • 2-(Difluoromethyl)Ornithine Hydrochloride (1:1)
  • 2-(Difluoromethyl)Ornithine Hydrochloride Hydrate
  • <span class="text-smallcaps">DL</span>-Ornithine, 2-(difluoromethyl)-, monohydrochloride
  • DFMO HCl
  • Eflornithine HCl
  • Eflornithine HCl(anhydrous)
  • Flornithine
  • Flornithine Hcl
  • See more synonyms
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