CAS 68377-92-4

Arotinolol

Description:

Arotinolol is a pharmaceutical compound classified as a non-selective beta-adrenergic antagonist, primarily used for its antihypertensive properties. It exhibits both beta-blocking and alpha-adrenergic blocking activities, which contribute to its effectiveness in managing high blood pressure and certain cardiovascular conditions. The compound is known to influence heart rate and vascular resistance, leading to reduced cardiac output and lower blood pressure. Arotinolol is also recognized for its potential to improve peripheral circulation. In terms of its chemical structure, it contains a phenolic moiety and an aliphatic side chain, which are essential for its biological activity. The substance is typically administered orally and has a favorable pharmacokinetic profile, allowing for effective absorption and distribution in the body. As with many beta-blockers, potential side effects may include fatigue, dizziness, and gastrointestinal disturbances. Due to its pharmacological properties, Arotinolol has been studied for various therapeutic applications beyond hypertension, including anxiety and certain types of arrhythmias.

Formula: C₁₅H₂₁N₃O₂S₃

InChI: InChI=1S/C15H21N3O2S3/c1-15(2,3)17-6-9(19)7-21-14-18-10(8-22-14)11-4-5-12(23-11)13(16)20/h4-5,8-9,17,19H,6-7H2,1-3H3,(H2,16,20)

InChI key: InChIKey=BHIAIPWSVYSKJS-UHFFFAOYSA-N

SMILES: C(N)(=O)C=1SC(=CC1)C=2N=C(SCC(CNC(C)(C)C)O)SC2

Synonyms:

• 2-(3-tert-Butylamino-2-hydroxypropylthio)-4-(5-carbamoyl-2-thienyl)thiazole
• 2-Thiophenecarboxamide, 5-[2-[[3-[(1,1-dimethylethyl)amino]-2-hydroxypropyl]thio]-4-thiazolyl]-
• 5-[2-[[3-[(1,1-Dimethylethyl)amino]-2-hydroxypropyl]thio]-4-thiazolyl]-2-thiophenecarboxamide
• Arottnolol
• NSC 317940
• Arotinolol
• (±)-Arotinolol

2-Thiophenecarboxamide,5-[2-[[3-[(1,1-dimethylethyl)amino]-2-hydroxypropyl]thio]-4-thiazolyl]-

CAS: 68377-92-4

Formula: C₁₅H₂₁N₃O₂S₃

Purity: 95%

Color and Shape: Solid

Molecular weight: 371.5411

Ref: IN-DA00F9UQ

Arotinolol

CAS: 68377-92-4

Formula: C₁₅H₂₁N₃O₂S₃

Molecular weight: 371.54

Ref: 7W-GP2047

Arotinolol

Controlled Product

CAS: 68377-92-4

Applications Arotinolol is both and alpha- and beta-adrenoceptor antagonist and is used to treat essential tremors and hypertension.
References Kuroda, Y., et al.: Neurology, 38, 650 (1988); Miyagishi, A., et al.: Arch. Pharmacodyn. Ther., 271, 249 (1984); Wu, H., et al.: Hypertens. Res.: Off. J. Jpn. Soc. Hypertens., 24, 605 (2001)

Formula: C₁₅H₂₁N₃O₂S₃

Color and Shape: Neat

Molecular weight: 371.54

Ref: TR-A771500

Arotinolol-D5 Hydrochloride

Controlled Product

CAS: 68377-92-4

Stability Hygroscopic
Applications Arotinolol-D5 Hydrochloride, is a labelled analogue of Arotinolol (A771500).

Formula: C₁₅H₁₆D₅N₃O₂S₃·HCl

Color and Shape: Neat

Molecular weight: 413.03

Ref: TR-A771502

5-(2-((3-(tert-Butylamino)-2-hydroxypropyl)thio)thiazol-4-yl)thiophene-2-carboxamide

CAS: 68377-92-4

Formula: C₁₅H₂₁N₃O₂S₃

Purity: 95%

Molecular weight: 371.53

Ref: 10-F324647

Arotinolol

CAS: 68377-92-4

Arotinolol is a nonselective α/β-adrenergic receptor blocker and a vasodilating β-blocker. Arotinolol also shows potency for inhibiting the binding of the radioligand [125I-ICYP] to [5HT1B-serotonergic] receptor sites. It is an antihypertensive agent.

Formula: C₁₅H₂₁N₃O₂S₃

Color and Shape: White Solid

Molecular weight: 371.54

Ref: TM-T10371