CAS 68406-26-8

Ginsenoside Rb3

Description:

Ginsenoside Rb3 is a triterpenoid saponin primarily found in ginseng, a plant renowned for its medicinal properties. It is one of the many ginsenosides, which are the active compounds believed to contribute to ginseng's health benefits. Ginsenoside Rb3 is characterized by its complex molecular structure, which includes a steroid-like backbone with multiple sugar moieties attached, influencing its solubility and bioactivity. This compound is known for its potential pharmacological effects, including anti-inflammatory, antioxidant, and neuroprotective properties. Research suggests that Ginsenoside Rb3 may enhance cognitive function and exhibit cardioprotective effects, making it of interest in both traditional medicine and modern pharmacology. Its mechanism of action often involves modulation of various signaling pathways, contributing to its therapeutic potential. As with many natural compounds, the bioavailability and efficacy of Ginsenoside Rb3 can be influenced by factors such as dosage, formulation, and individual metabolic differences.

Formula: C₅₃H₉₀O₂₂

InChI: InChI=1/C53H90O22/c1-8-23(2)10-9-15-53(7,75-48-44(67)40(63)38(61)31(72-48)22-69-46-42(65)35(58)28(57)21-68-46)25-13-16-52(6)24-11-12-32-50(3,4)33(14-17-51(32,5)26(24)18-27(56)34(25)52)73-49-45(41(64)37(60)30(20-55)71-49)74-47-43(66)39(62)36(59)29(19-54)70-47/h10,24-49,54-67H,8-9,11-22H2,1-7H3/b23-10+/t24?,25?,26?,27-,28+,29+,30+,31+,32?,33?,34?,35-,36+,37+,38+,39-,40+,41-,42+,43+,44+,45+,46-,47-,48-,49-,51+,52+,53+/m0/s1

InChI key: InChIKey=NODILNFGTFIURN-USYOXQFSSA-N

SMILES: C[C@]12[C@@]3(C)[C@@]([C@@]([C@@](O[C@@H]4O[C@H](CO[C@H]5[C@H](O)[C@@H](O)[C@H](O)CO5)[C@@H](O)[C@H](O)[C@H]4O)(CCC=C(C)C)C)(CC3)[H])([C@H](O)C[C@@]1([C@]6(C)[C@@](CC2)(C(C)(C)[C@@H](O[C@H]7[C@H](O[C@@H]8O[C@H](CO)[C@@H](O)[C@H](O)[C@H]8O)[C@@H](O)[C@H](O)[C@@H](CO)O7)CC6)[H])[H])[H]

Synonyms:

• (1R,4E)-1-{(8xi,9xi,12α,13xi,14β)-3-[(2-O-β-D-glucopyranosyl-β-D-glucopyranosyl)oxy]-12-hydroxy-4,4,10,14-tetramethylgonan-17-yl}-1,5-dimethylhept-4-en-1-yl 6-O-β-D-xylopyranosyl-β-D-allopyranoside
• (3β,12β)-3-[(2-O-β-<span class="text-smallcaps">D</smallcap>-Glucopyranosyl-β-<smallcap>D</smallcap>-glucopyranosyl)oxy]-12-hydroxydammar-24-en-20-yl 6-O-β-<smallcap>D</smallcap>-xylopyranosyl-β-<smallcap>D</span>-glucopyranoside
• Dammarane, β-<span class="text-smallcaps">D</span>-glucopyranoside deriv.
• Ginsenoside Rb₃
• Gypenoside IV
• alpha-D-Glucopyranoside, (3-beta,12-beta)-3-((2-O-beta-D-glucopyranosyl-beta-D-glucopyranosyl)oxy)-12-hydroxydammar-24-en-20-yl 6-O-beta-D-xylopyranosyl-
• β-<span class="text-smallcaps">D</smallcap>-Glucopyranoside, (3β,12β)-3-[(2-O-β-<smallcap>D</smallcap>-glucopyranosyl-β-<smallcap>D</smallcap>-glucopyranosyl)oxy]-12-hydroxydammar-24-en-20-yl 6-O-β-<smallcap>D</span>-xylopyranosyl-
• β-D-Glucopyranoside, (3β,12β)-3-[(2-O-β-D-glucopyranosyl-β-D-glucopyranosyl)oxy]-12-hydroxydammar-24-en-20-yl 6-O-β-D-xylopyranosyl-
• Dammarane, β-D-glucopyranoside deriv.
• (3β,12β)-3-[(2-O-β-D-Glucopyranosyl-β-D-glucopyranosyl)oxy]-12-hydroxydammar-24-en-20-yl 6-O-β-D-xylopyranosyl-β-D-glucopyranoside
• Ginsenoside Rb3
• β-D-Glucopyranoside, (3β,12β)-3-[(2-O-β-D-
• NH25835
• Ginsenoside Rb3 ,98%
• [3β-[[2-O-(β-D-Glucopyranosyl)-β-D-glucopyranosyl]oxy]-12β-hydroxy-5α-dammar-24-en-20-yl]6-O-(β-D-xylopyranosyl)-β-D-glucopyranoside
• glucopyranosyl)oxy)-12-hydroxydammar-24-en-20-yl6-o-beta-d-xylopyranosyl-
• xylopyranosyl-
• (3-beta,12-beta)-3-((2-o-beta-d-glucopyranosyl-beta-d-alpha-d-glucopyranosid
• Ginsenoside Rb3, 98%, from Panax ginseng C. A. Mey.
• GINSENOSIDE Rb3(SH)
• (2S,3R,4S,5S,6R)-2-[[(2R,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-2-[[(10R,12S,14R)-12-hydroxy-4,4,10,14-tetramethyl-17-[(E,2R)-6-methyl-2-[[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-[[(2S,3R,4S,5R)-3,4
• hydroxydammar-24-en-20-yl6-O-β-D-

Ginsenoside Rb3

CAS: 68406-26-8

Ginsenoside Rb3 analytical standard provided with w/w absolute assay, to be used for quantitative titration.

Formula: C₅₃H₉₀O₂₂

Purity: (HPLC) ≥97%

Color and Shape: Powder

Molecular weight: 1079.29

Ref: 11-0151S

Ginsenoside Rb3

CAS: 68406-26-8

Formula: C₅₃H₉₀O₂₂

Purity: ≥ 98.0%

Color and Shape: White to off-white crystalline powder

Molecular weight: 1079.27

Ref: 7W-GC9541

Ginsenoside Rb3

CAS: 68406-26-8

Ginsenoside Rb3 has anti-myocardial ischemia-reperfusion injury, neuroprotective, antidepressant-like, and antioxidant effects, it also possesses the potential of the clinical use in preventing and treating diabetes. Ginsenoside Rb3 significantly attenuates the changes of creatine kinase activity and lactate dehydrogenase activity, exhibits inhibitory effect on TNFα-induced NF-κB transcriptional activity with an IC50 of 8.2 μM in 293T cell lines, it also inhibits the induction of COX-2 and iNOS mRNA.

Formula: C₅₃H₉₀O₂₂

Purity: 95%~99%

Molecular weight: 1079.28

Ref: BP-BP0659

Ginsenoside Rb3

CAS: 68406-26-8

Formula: C₅₃H₉₀O₂₂

Molecular weight: 1079.28

Ref: 4Z-G-157024

Ginsenoside Rb3

CAS: 68406-26-8

Ginsenoside Rb3 (Gypenoside IV) is a natural triterpenoid saponin, exhibiting inhibition effect on TNFα-induced NF-κB transcriptional activity.

Formula: C₅₃H₉₀O₂₂

Purity: 98% - 99.98%

Color and Shape: Solid

Molecular weight: 1079.27

Ref: TM-T3918

Ginsenoside rb3

CAS: 68406-26-8

Natural glycoside

Formula: C₅₃H₉₀O₂₂

Purity: ≥ 90.0 % (HPLC)

Color and Shape: Powder

Molecular weight: 1079.29

Ref: 5G-89679

Ginsenoside Rb3

Controlled Product

CAS: 68406-26-8

Stability Hygroscopic
Applications Ginsenoside Rb3 inhibits the upregulation of phospho-IκB-α and nuclear translocation of NF-κB subunit p65 induced by glucose deprivation then reperfusion.
References Ma, L., et. al.: PloS One, 9, e103628/1-e103628/12 (2014)

Formula: C₅₃H₉₀O₂₂

Color and Shape: Neat

Molecular weight: 1079.27

Ref: TR-G387610

Ginsenoside Rb3

CAS: 68406-26-8

Ginsenoside Rb3 is a natural saponin compound, which is a type of ginsenoside derived from the root of Panax ginseng. The source of Ginsenoside Rb3, Panax ginseng, is a perennial plant widely utilized in traditional medicine for its pharmacological properties.

Formula: C₅₃H₉₀O₂₂

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 1,079.27 g/mol

Ref: 3D-OG09286