CAS 68475-42-3

Anagrelide

Description:

Anagrelide is a synthetic compound primarily used as a medication to reduce elevated platelet counts in conditions such as essential thrombocythemia. It functions as a selective inhibitor of megakaryocyte differentiation and platelet production, thereby decreasing the risk of thrombotic events associated with high platelet levels. The chemical structure of Anagrelide includes a pyrimidinone core, which contributes to its pharmacological activity. It is typically administered orally and is metabolized in the liver, with its effects being dose-dependent. Common side effects may include headache, dizziness, and gastrointestinal disturbances. Anagrelide's mechanism of action involves the inhibition of cyclic adenosine monophosphate (cAMP) phosphodiesterase, leading to increased cAMP levels, which in turn affects platelet production. Due to its specific action on megakaryocytes, Anagrelide is distinct from other antiplatelet agents, making it a valuable option in managing certain hematological disorders. As with any medication, it is essential to monitor patients for potential adverse effects and interactions with other drugs.

Formula: C₁₀H₇Cl₂N₃O

InChI: InChI=1S/C10H7Cl2N3O/c11-6-1-2-7-5(9(6)12)3-15-4-8(16)14-10(15)13-7/h1-2H,3-4H2,(H,13,14,16)

InChI key: InChIKey=OTBXOEAOVRKTNQ-UHFFFAOYSA-N

SMILES: ClC1=C2C(NC=3N(C2)CC(=O)N3)=CC=C1Cl

Synonyms:

• 11-6-1
• 6,7-Dichloro-1,5-dihydroimidazo[2,1-b]quinazolin-2(3H)-one
• 6,7-Dichloro-5,10-dihydroimidazo[2,1-b]quinazolin-2(3H)-one
• 68475-42-3
• Bl 4162A
• Xagrid
• imidazo[2,1-b]quinazolin-2(3H)-one, 6,7-dichloro-1,5-dihydro-
• imidazo[2,1-b]quinazolin-2(3H)-one, 6,7-dichloro-5,10-dihydro-
• Anagrelide

6,7-dichloro-5,10-dihydro-3H-imidazo[2,1-b]quinazolin-2-one

CAS: 68475-42-3

Formula: C₁₀H₇Cl₂N₃O

Purity: 98%

Color and Shape: Solid

Molecular weight: 256.0881

Ref: IN-DA00IBU8

Anagrelide

CAS: 68475-42-3

Anagrelide

Purity: ≥98%

Molecular weight: 256.09g/mol

Ref: 54-BUP00378

Anagrelide

CAS: 68475-42-3

Formula: C₁₀H₇Cl₂N₃O

Molecular weight: 256.09

Ref: 7W-GP3089

Anagrelide-13C3

CAS: 68475-42-3

Formula: C₇₁₃C₃H₇Cl₂N₃O

Color and Shape: White To Off-White Solid

Molecular weight: 259.06

Ref: 4Z-A-10301

Anagrelide

CAS: 68475-42-3

Anagrelide (Xagrid) is a Platelet-reducing Agent.

Formula: C₁₀H₇Cl₂N₃O

Purity: 99.53% - >99.99%

Color and Shape: Solid

Molecular weight: 256.09

Ref: TM-T0160

Anagrelide

CAS: 68475-42-3

Formula: C₁₀H₇Cl₂N₃O

Molecular weight: 256.09

Ref: ST-EA-CP-A76000

Anagrelide

CAS: 68475-42-3

Anagrelide is a molecule that inhibits the JAK2 kinase and has been shown to inhibit the process of angiogenesis. It is used in the treatment of myeloproliferative disorders, such as polycythemia vera, thrombocythemia, or leukemia. The effects of anagrelide on the cardiovascular system have been studied in detail. Anagrelide has also been shown to be effective in experimental models for human diseases such as cancer and arthritis.

Formula: C₁₀H₇Cl₂N₃O

Purity: Min. 95%

Color and Shape: White/Off-White Solid

Molecular weight: 256.09 g/mol

Ref: 3D-FA168205