CAS 68498-26-0

Ethenodeoxycytidine

Description:

Ethenodeoxycytidine, also known as 5-ethenyl-2'-deoxycytidine, is a synthetic nucleoside analog of cytidine. It is characterized by the presence of an ethenyl group at the 5-position of the pyrimidine ring, which distinguishes it from natural nucleosides. This modification can influence its biological activity, particularly in the context of DNA synthesis and repair. Ethenodeoxycytidine is often studied for its potential role in cancer research, as it can interfere with normal cellular processes and may be incorporated into DNA, leading to mutations or cell death. The compound is typically used in laboratory settings for various biochemical assays and studies related to nucleic acid chemistry. Its CAS number, 68498-26-0, is a unique identifier that facilitates the identification and procurement of the substance in scientific research. As with many nucleoside analogs, the pharmacological properties of ethenodeoxycytidine are of interest, particularly in the development of antiviral and anticancer therapies.

Formula: C₁₁H₁₃N₃O₄

InChI: InChI=1/C11H13N3O4/c15-6-8-7(16)5-10(18-8)14-3-1-9-12-2-4-13(9)11(14)17/h1-4,7-8,10,15-16H,5-6H2/t7-,8+,10+/m0/s1

InChI key: InChIKey=UFLBVEMEAYZXKY-QXFUBDJGSA-N

SMILES: O=C1N([C@@H]2O[C@H](CO)[C@@H](O)C2)C=CC=3N1C=CN3

Synonyms:

• 3,N⁴-Etheno-2′-deoxycytidine
• 3,N⁴-Etheno-dC
• 3,N⁴-Ethenodeoxycytidine
• 6-(2-Deoxy-β-<span class="text-smallcaps">D</span>-erythro-pentofuranosyl)imidazo[1,2-c]pyrimidin-5(6H)-one
• Ethenodeoxycytidine
• Imidazo(1,2-c)pyrimidin-5(6H)-one, 6-(2-deoxy-beta-D-erythro-pentofuranosyl)-
• Imidazo[1,2-c]pyrimidin-5(6H)-one, 6-(2-deoxy-β-<span class="text-smallcaps">D</span>-erythro-pentofuranosyl)-
• 3,N4-Etheno-2′-deoxycytidine
• Imidazo[1,2-c]pyrimidin-5(6H)-one, 6-(2-deoxy-β-D-erythro-pentofuranosyl)-
• 3,N4-Ethenodeoxycytidine
• 6-(2-Deoxy-β-D-erythro-pentofuranosyl)imidazo[1,2-c]pyrimidin-5(6H)-one

3,N4-Etheno-2’-deoxycytidine

Controlled Product

CAS: 68498-26-0

Applications 3,N4-Etheno-2’-deoxycytidine is a biomarkers for assessing oxidative stress. Formed in human white blood cells.
References Shen, M., et al.: Sci. Total Environ., 543, 267-273 (2016); Li, H., et al.: Free Radical Res., 49, 1049-1054 (2015); Cui, S., et al.: Int. J. Environ. Res. Public Health, 11, 10902-10914 (2014)

Formula: C₁₁H₁₃N₃O₄

Color and Shape: Neat

Molecular weight: 251.239

Ref: TR-E677900

N4-Etheno 2'-deoxycytidine

CAS: 68498-26-0

N4-Etheno 2'-deoxycytidine is an aromatic hydrocarbon that has been shown to be a potent inhibitor of DNA synthesis. It binds covalently with the N4 position of deoxycytidine in DNA, thereby inhibiting transcription and replication. This drug has been shown to be a potent inhibitor of DNA synthesis in human cells when it is added to the culture medium, but it does not inhibit protein synthesis. N4-Etheno 2'-deoxycytidine can also react with hydrogen bonds in cellular proteins and nucleosides that are involved in DNA repair mechanisms. This drug is reactive and may cause oxidative damage to cellular components, which may lead to carcinogenesis.

Formula: C₁₁H₁₃N₃O₄

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 251.24 g/mol

Ref: 3D-NE04078

3,N4-Etheno-2’-deoxycytidine-13C,15N2

Controlled Product

CAS: 68498-26-0

Applications Isotope labelled 3,N4-Etheno-2’-deoxycytidine is a biomarkers for assessing oxidative stress. Formed in human white blood cells.
References Shen, M., et al.: Sci. Total Environ., 543, 267-273 (2016); Li, H., et al.: Free Radical Res., 49, 1049-1054 (2015); Cui, S., et al.: Int. J. Environ. Res. Public Health, 11, 10902-10914 (2014)

Formula: C₁₀₁₃CH₁₃N₁₅N₂O₄

Color and Shape: Neat

Molecular weight: 254.22

Ref: TR-E677902

3, N4-Etheno-2'-deoxycytidine-13C5

Controlled Product

CAS: 68498-26-0

Applications 3, N4-Etheno-2'-deoxycytidine-13C5is caused by exposure to pollutants. It is an isotopically labeled analog of the 2’-Deoxyguanosine adduct.

Formula: C₅C₆H₆N₃O₄

Color and Shape: Neat

Molecular weight: 249.146

Ref: TR-E677908