CAS 68528-80-3

Disuccinimidyl suberate

Description:

Disuccinimidyl suberate (DSS) is a crosslinking reagent commonly used in biochemistry and molecular biology for the covalent linkage of proteins and other biomolecules. It features a symmetrical structure with two succinimidyl ester groups attached to a suberic acid backbone, which allows it to effectively crosslink amine-containing compounds, such as proteins, through nucleophilic attack on the succinimidyl groups. DSS is particularly valued for its ability to create stable amide bonds, facilitating the study of protein interactions, complex formation, and structural analysis. The reagent is soluble in organic solvents and exhibits a relatively long half-life, making it suitable for various experimental conditions. Additionally, DSS is often used in applications such as immunoprecipitation, protein labeling, and the preparation of protein conjugates. However, care must be taken when handling DSS, as it can be reactive and may require specific conditions to minimize unwanted side reactions. Overall, DSS is a versatile tool in the field of protein chemistry and bioconjugation.

Formula: C₁₆H₂₀N₂O₈

InChI: InChI=1S/C16H20N2O8/c19-11-7-8-12(20)17(11)25-15(23)5-3-1-2-4-6-16(24)26-18-13(21)9-10-14(18)22/h1-10H2

InChI key: InChIKey=ZWIBGKZDAWNIFC-UHFFFAOYSA-N

SMILES: O(C(CCCCCCC(ON1C(=O)CCC1=O)=O)=O)N2C(=O)CCC2=O

Synonyms:

• 2,5-Pyrrolidinedione, 1,1′-[(1,8-dioxo-1,8-octanediyl)bis(oxy)]bis-
• Disuccinimidyl suberate
• Disuccinimidylsuberate
• NSC 340008
• Octanedioic acid di-N-hydroxysuccinimide ester
• Octanedioic acid, 1,8-bis(2,5-dioxo-1-pyrrolidinyl) ester
• Suberic acid bis(N-hydroxy succinimide ester)

Di(N-succinimidyl) Suberate

CAS: 68528-80-3

Formula: C₁₆H₂₀N₂O₈

Purity: >98.0%(HPLC)(N)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 368.34

Ref: 3B-D3895

Disuccinimidyl suberate, 97%

CAS: 68528-80-3

Disuccinimidyl suberate is a homobifunctional amine-reactive crosslinker. It is usually coupled to molecules containing primary amines via amide bonds buffered at pH 7.5 (6.5-8.5). It incorporates an 8-atom spacer arm. This Thermo Scientific Chemicals brand product was originally part of the Alfa Ae

Formula: C₁₆H₂₀N₂O₈

Purity: 97%

Molecular weight: 368.34

Ref: 02-H51771

Bis(2,5-dioxopyrrolidin-1-yl) octanedioate

CAS: 68528-80-3

Formula: C₁₆H₂₀N₂O₈

Purity: 97%

Color and Shape: Solid

Molecular weight: 368.3386

Ref: IN-DA003UG1

DSS Crosslinker

CAS: 68528-80-3

DSS Crosslinker

Purity: ≥98%

Molecular weight: 368.34g/mol

Ref: 54-BUP16919

Disuccinimidyl suberate

CAS: 68528-80-3

Disuccinimidyl suberate

Formula: C₁₆H₂₀N₂O₈

Purity: 97%

Color and Shape: white solid

Molecular weight: 368.34g/mol

Ref: 54-BICL100

DSS Crosslinker

CAS: 68528-80-3

DSS Crosslinker: non-cleavable, homobifunctional ADC linker with amine-reactive NHS ends, 11.4Å spacer, for intracellular protein conjugation.

Formula: C₁₆H₂₀N₂O₈

Purity: 99.04% - 99.72%

Color and Shape: Solid

Molecular weight: 368.34

Ref: TM-T15176

Disuccinimidyl suberate

CAS: 68528-80-3

Disuccinimidyl suberate is a water-soluble, non-toxic compound that has been used as a cross-linking agent in the preparation of proteins for immunological and biochemical studies. Disuccinimidyl suberate reacts with carboxyl groups of proteins and exhibits chemiluminescence upon hydrolysis. This reaction can be used to measure the amount of protein present in samples. Disuccinimidyl suberate has been shown to inhibit virus growth by interfering with viral membrane fusion. It also inhibits the replication of human immunodeficiency virus type 1 (HIV-1) by binding to gp120, which is an envelope glycoprotein on the surface of HIV-1. Disuccinimidyl suberate also binds to neurotrophic factors, such as nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and glial cell line-derived neurotrophic factor (GDNF

Formula: C₁₆H₂₀N₂O₈

Purity: Min. 98 Area-%

Color and Shape: White Powder

Molecular weight: 368.34 g/mol

Ref: 3D-FD52745

Bis(2,5-dioxopyrrolidin-1-yl) octanedioate

CAS: 68528-80-3

Formula: C₁₆H₂₀N₂O₈

Purity: 95%

Color and Shape: Solid

Molecular weight: 368.342

Ref: 10-F448714

Suberic Acid-d4 Bis(N-Hydroxysuccinimide Ester)

Controlled Product

CAS: 68528-80-3

Applications Suberic Acid-d4 Bis(N-Hydroxysuccinimide Ester) is the isotope labelled cell membrane permeable crosslinking agent.
References Lin, P.C., et al.: Biomacromole., 14, 160 (2013); Bezouska, K., et al.: Biocon. Chem., 23, 2032 (2012);

Formula: C₁₆D₄H₁₆N₂O₈

Color and Shape: Neat

Molecular weight: 372.363

Ref: TR-S777542