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CAS 68538-85-2

:

<span class="text-smallcaps">L</span>-Folinic acid

Description:
L-Folinic acid, also known as leucovorin, is a derivative of folic acid and serves as a crucial cofactor in various biochemical processes, particularly in the synthesis of nucleic acids and amino acids. It is characterized by its ability to enhance the effects of certain chemotherapeutic agents, such as methotrexate, by providing a source of reduced folate that can bypass the inhibition of dihydrofolate reductase. This compound is often utilized in clinical settings to mitigate the toxic effects of folate antagonists and to treat conditions like megaloblastic anemia. L-Folinic acid is typically administered via injection or orally, and its solubility in water facilitates its absorption and distribution in biological systems. The substance is generally well-tolerated, with a low incidence of side effects, making it a valuable therapeutic agent. Its chemical structure includes a pteridine ring, a para-aminobenzoic acid moiety, and a glutamic acid residue, which contribute to its biological activity and interaction with enzymes involved in folate metabolism.
Formula:C20H23N7O7
InChI:InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32)/t12-,13-/m0/s1
InChI key:InChIKey=VVIAGPKUTFNRDU-STQMWFEESA-N
SMILES:C(=O)N1C2=C(NC[C@@H]1CNC3=CC=C(C(N[C@@H](CCC(O)=O)C(O)=O)=O)C=C3)NC(N)=NC2=O
Synonyms:
  • N-[4-[[[(6S)-2-Amino-5-formyl-3,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl]methyl]amino]benzoyl]-L-glutamic acid
  • L-Glutamic acid, N-[4-[[[(6S)-2-amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl]methyl]amino]benzoyl]-
  • L-Glutamic acid, N-[4-[[[(6S)-2-amino-5-formyl-3,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl]methyl]amino]benzoyl]-
  • (6S)-5-Formyl-5,6,7,8-tetrahydrofolic acid
  • L-Glutamic acid, N-[4-[[(2-amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-, (S)-
  • Folinic Acid Impurity H (Levofolinic Acid)
  • (-)-N-[4-[[[(6S)-2-Amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxopteridin-6β-yl]methyl]amino]benzoyl]-L-glutamic acid
  • Impurity H of Calcium Levofolinate
  • (S)-Leucovorin
  • Folinic Acid EP Impurity H
  • See more synonyms
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