CAS 685898-44-6

PX 478

Description:

PX-478, with the CAS number 685898-44-6, is a small molecule inhibitor primarily known for its role in cancer research. It functions as a selective inhibitor of hypoxia-inducible factor 1-alpha (HIF-1α), a transcription factor that plays a crucial role in cellular responses to low oxygen levels and is often overexpressed in various tumors, contributing to tumor growth and metastasis. PX-478 has been studied for its potential to inhibit tumor growth by disrupting the HIF-1α pathway, thereby affecting the expression of genes involved in angiogenesis, metabolism, and cell survival. The compound is typically characterized by its moderate solubility in organic solvents and relatively low solubility in water, which can influence its bioavailability and pharmacokinetics. Research indicates that PX-478 may enhance the efficacy of other cancer therapies, making it a subject of interest in combination treatment strategies. However, as with any investigational drug, further studies are necessary to fully understand its therapeutic potential and safety profile.

Formula: C₁₃H₁₈Cl₂N₂O₃·2ClH

InChI: InChI=1S/C13H18Cl2N2O3.2ClH/c14-5-7-17(20,8-6-15)11-3-1-10(2-4-11)9-12(16)13(18)19;;/h1-4,12H,5-9,16H2,(H,18,19);2*1H/t12-;;/m0../s1

InChI key: InChIKey=GIGCDIVNDFQKRA-LTCKWSDVSA-N

SMILES: N(CCCl)(CCCl)(=O)C1=CC=C(C[C@@H](C(O)=O)N)C=C1.Cl

Synonyms:

• L-Phenylalanine, 4-[bis(2-chloroethyl)oxidoamino]-, dihydrochloride
• PX 478
• L-Phenylalanine, 4-[bis(2-chloroethyl)oxidoamino]-, hydrochloride (1:2)
• (S)-4-(2-Amino-2-carboxyethyl)-N,N-bis(2-chloroethyl)aniline oxide dihydrochloride

L-Phenylalanine, 4-[bis(2-chloroethyl)oxidoaMino]-, (Hydrochloride) (1

CAS: 685898-44-6

Formula: C₁₃H₂₂Cl₄N₂O₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 396.1374

Ref: IN-DA00FC0T

PX-478

CAS: 685898-44-6

PX-478

Purity: ≥95%

Molecular weight: 394.12g/mol

Ref: 54-BUP13138

PX-478

CAS: 685898-44-6

PX-478 is a HIF-1α inhibitor with selectivity, oral activity, and blood-brain barrier permeability.

Formula: C₁₃H₂₀Cl₄N₂O₃

Purity: 97% - 99.79%

Color and Shape: Solid

Molecular weight: 394.12

Ref: TM-T6961

PX-478

CAS: 685898-44-6

PX-478 is a drug that inhibits the function of P-glycoprotein (P-gp), which is a protein that transports certain drugs out of cells. PX-478 has been shown to inhibit the proliferation of tumor cells in vitro in response to radiation. It also inhibits the HIF-1α pathway, which leads to apoptosis and prevents tumor growth. In vivo, PX-478 inhibited tumor growth and prolonged survival time in a squamous carcinoma model system. The drug binds to the DNA response element upstream of the polymerase chain gene, thereby inhibiting transcription and translation.

Formula: C₁₃H₂₀Cl₄N₂O₃

Purity: Min. 95%

Molecular weight: 394.12 g/mol

Ref: 3D-KCB89844