CAS 685898-44-6: PX 478

Description: PX-478, with the CAS number 685898-44-6, is a small molecule inhibitor primarily known for its role in cancer research. It functions as a selective inhibitor of hypoxia-inducible factor 1-alpha (HIF-1α), a transcription factor that plays a crucial role in cellular responses to low oxygen levels and is often overexpressed in various tumors, contributing to tumor growth and metastasis. PX-478 has been studied for its potential to inhibit tumor growth by disrupting the HIF-1α pathway, thereby affecting the expression of genes involved in angiogenesis, metabolism, and cell survival. The compound is typically characterized by its moderate solubility in organic solvents and relatively low solubility in water, which can influence its bioavailability and pharmacokinetics. Research indicates that PX-478 may enhance the efficacy of other cancer therapies, making it a subject of interest in combination treatment strategies. However, as with any investigational drug, further studies are necessary to fully understand its therapeutic potential and safety profile.

Formula: C₁₃H₁₈Cl₂N₂O₃·2ClH

InChI: InChI=1S/C13H18Cl2N2O3.2ClH/c14-5-7-17(20,8-6-15)11-3-1-10(2-4-11)9-12(16)13(18)19;;/h1-4,12H,5-9,16H2,(H,18,19);2*1H/t12-;;/m0../s1

InChI key: InChIKey=GIGCDIVNDFQKRA-LTCKWSDVSA-N

SMILES: Cl.O=C(O)C(N)CC1=CC=C(C=C1)N(=O)(CCCl)CCCl

Synonyms:

• L-Phenylalanine, 4-[bis(2-chloroethyl)oxidoamino]-, dihydrochloride
• PX 478
• L-Phenylalanine, 4-[bis(2-chloroethyl)oxidoamino]-, hydrochloride (1:2)
• (S)-4-(2-Amino-2-carboxyethyl)-N,N-bis(2-chloroethyl)aniline oxide dihydrochloride

L-Phenylalanine, 4-[bis(2-chloroethyl)oxidoaMino]-, (Hydrochloride) (1

CAS: 685898-44-6

• Formula: C₁₃H₂₀Cl₄N₂O₃
• Purity: 98%
• Color and Shape: Solid
• Molecular weight: 394.1215

PX-478

CAS: 685898-44-6

• Purity: ≥95%
• Molecular weight: 394.12g/mol

PX-478

CAS: 685898-44-6

PX-478 is a HIF-1α inhibitor with selectivity, oral activity, and blood-brain barrier permeability.

• Formula: C₁₃H₂₀Cl₄N₂O₃
• Purity: 97% - ≥98%
• Color and Shape: Solid
• Molecular weight: 394.12

PX-478

CAS: 685898-44-6

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• Formula: C₁₃H₂₀Cl₄N₂O₃
• Purity: Min. 95%
• Molecular weight: 394.12 g/mol