CAS 68652-37-9

tetrasialoganglioside gq1B from*bovine brain

Description:

Tetrasialoganglioside GQ1b is a complex glycosphingolipid primarily found in the nervous tissue of mammals, particularly in the bovine brain. It is characterized by its structure, which includes a ceramide backbone linked to a carbohydrate moiety containing four sialic acid residues. This unique composition contributes to its role in cell signaling and recognition processes in the nervous system. Tetrasialoganglioside GQ1b is particularly significant in the context of neuronal function and has been implicated in various neurological conditions. Its presence is associated with the modulation of synaptic transmission and neuroprotection. The CAS number 68652-37-9 specifically identifies this compound, facilitating its recognition in scientific literature and databases. As a member of the ganglioside family, GQ1b exhibits properties such as amphiphilicity, which allows it to interact with lipid membranes and proteins, influencing cellular interactions and signaling pathways. Understanding its characteristics is crucial for research in neurobiology and potential therapeutic applications.

Synonyms:

• GQ1b Ganglioside
• Ganglioside GQ1B

Ganglioside GQ1b Mixture (sodium salt)

CAS: 68652-37-9

Ganglioside GQ1b, a tetrasialoganglioside, prompts cell differentiation and phosphorylation in neurons and skin cells.

Formula: C₁₀₆H₁₇₈N₆O₅₅₄Na

Color and Shape: Solid

Molecular weight: 2508.5

Ref: TM-T35553

Tetrasialoganglioside GQ1b

CAS: 68652-37-9

Formula: Unspecified

Purity: >98%

Color and Shape: Solid

Ref: 48-56-1108

GQ1b-Ganglioside

CAS: 68652-37-9

Formula: C₁₀₆H₁₇₈N₆O₅₅·4Na

Purity: ≥ 98%

Color and Shape: White to off-white solid or powder

Molecular weight: 2508.6

Ref: 7W-GC8688

GQ1b-Ganglioside sodium

CAS: 68652-37-9

GQ1b ganglioside (sodium salt) has a core tetrasaccharide structure (Galβ1,3GalNAcβ1,4Galβ1,4Glc) with two sialic acids (NeuAc) linked α2,3/α2,8 to the inner galactose residue, two sialic acids (NeuAc) linked α2,3/α2,8 to the terminal galactose residue and ceramide linked β to position 1 on the reducing terminal glucose residue (Ledeen, 2009). Anti-GQ1b ganglioside antibody is associated with Miller Fisher syndrome and is also found in patients with related conditions that may share the same pathogenic mechanism, such as, Bickerstaff brainstem encephalitis. Thus, the measurement of the anti-GQ1b antibody in suspected cases of Miller Fisher syndrome is a useful diagnostic marker (Paparounas, 2004). It has been found that GQ1b ganglioside contributes to synaptic transmission and synapse formation. Low concentrations of GQ1b ganglioside, evoked dopamine (DA) release from laboratory tissues (Chen, 2018).

Formula: C₁₀₆H₁₈₂N₆O₅₆·4Na

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 2,528.55 g/mol

Ref: 3D-OG16190

GQ1b-Ganglioside ammonium

CAS: 68652-37-9

GQ1b ganglioside (ammonium salt) has a core tetrasaccharide structure (Galβ1,3GalNAcβ1,4Galβ1,4Glc) with two sialic acids (NeuAc) linked α2,3/α2,8 to the inner galactose residue, two sialic acids (NeuAc) linked α2,3/α2,8 to the terminal galactose residue, and ceramide linked β to position 1 on the reducing terminal glucose residue (Ledeen, 2009). Anti-GQ1b ganglioside antibody is associated with Miller Fisher syndrome and is also found in patients with related conditions that may share the same pathogenic mechanism, such as, Bickerstaff brainstem encephalitis. Thus, the measurement of anti-GQ1b antibody in suspected cases of Miller Fisher syndrome is a useful diagnostic marker (Paparounas, 2004). It has been found that GQ1b ganglioside contributes to synaptic transmissions and synapse formation. Low concentrations of GQ1b ganglioside, evoked dopamine (DA) release from laboratory tissues (Chen, 2018).

Formula: C₁₀₆H₁₈₂N₆O₅₆·xNH₄

Purity: Min. 95%

Ref: 3D-OG175969