CAS 686770-61-6

IWP-2

Description:

IWP-2, with the CAS number 686770-61-6, is a small molecule inhibitor primarily known for its role in modulating the Wnt signaling pathway. This compound is characterized by its ability to inhibit the activity of glycogen synthase kinase 3 (GSK-3), which is a key regulator in this pathway. By inhibiting GSK-3, IWP-2 promotes the stabilization of β-catenin, leading to enhanced Wnt signaling. This property makes IWP-2 a valuable tool in research, particularly in studies related to stem cell biology, developmental processes, and cancer, where Wnt signaling plays a critical role. IWP-2 is typically used in cell culture experiments and has been shown to influence cell proliferation and differentiation. Its chemical structure includes specific functional groups that contribute to its inhibitory activity, although detailed structural information is not provided here. As with any chemical substance, proper handling and safety protocols should be observed when working with IWP-2 in laboratory settings.

IWP-2

CAS: 686770-61-6

Formula: C₂₂H₁₈N₄O₂S₃

Purity: >96.0%(HPLC)

Color and Shape: White to Yellow to Orange powder to crystal

Molecular weight: 466.59

Ref: 3B-I1097

N-(6-Methylbenzo[D]Thiazol-2-Yl)-2-((4-Oxo-3-Phenyl-3,4,6,7-Tetrahydrothieno[3,2-D]Pyrimidin-2-Yl)Thio)Acetamide

CAS: 686770-61-6

N-(6-Methylbenzo[D]Thiazol-2-Yl)-2-((4-Oxo-3-Phenyl-3,4,6,7-Tetrahydrothieno[3,2-D]Pyrimidin-2-Yl)Thio)Acetamide

Purity: 98%

Molecular weight: 466.6g/mol

Ref: 54-OR1025613

IWP-2

CAS: 686770-61-6

IWP-2

Purity: ≥95%

Molecular weight: 466.6g/mol

Ref: 54-BUP10526

IWP-2

CAS: 686770-61-6

IWP-2 is a Wnt pathway inhibitor and an ATP-competitive CK1δ inhibitor. IWP-2 inhibits self-renewal of embryonic stem cells. Cost effective and quality assured.

Formula: C₂₂H₁₈N₄O₂S₃

Purity: 96.1% - 99.49%

Color and Shape: Solid

Molecular weight: 466.6

Ref: TM-T2702

IWP-2

CAS: 686770-61-6

Antagonist of Wnt signalling pathway by inhibiting the activity of Porcn, a member of the membrane-bound O-acyltransferase (MBOAT) family. Porcn is required for the palmitoylation of Wnt, mediating its secretion and signalling. Inhibits self-renewal in embryonic stem cells, whilst promoting differentiation to epiblast stem cells.

Formula: C₂₂H₁₈N₄O₂S₃

Purity: Min. 95%

Color and Shape: White To Off-White Solid

Molecular weight: 466.05919

Ref: 3D-FI24745

IWP-2

CAS: 686770-61-6

Applications IWP-2 is an inactivator of Porcn function; inhibitor of Wnt production. IWP-2 is useful in the treatment diseases and conditions such as cancer, degenerative diseases, type II diabetes and osteopetrosis.
References Poss, K., et al.: Dev. Biol., 222, 347 (2000), Tanaka, K., et al.: Eur. J. Biochem., 267, 4300 (2000), Clevers, H., et al.: Cell, 2006, 127, 469 (2006),

Formula: C₂₂H₁₈N₄O₂S₃

Color and Shape: Off White Powder

Molecular weight: 466.60

Ref: TR-I941600