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CAS 68726-28-3

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2',3'-dideoxyguanosine 5'-triphosphate*sodium

Description:
2',3'-Dideoxyguanosine 5'-triphosphate sodium (ddGTP) is a nucleotide analog that plays a significant role in molecular biology, particularly in DNA synthesis and sequencing. It is characterized by the absence of the hydroxyl group at the 2' position of the ribose sugar, which distinguishes it from the natural nucleotide guanosine triphosphate (GTP). This structural modification impedes further elongation of the DNA strand during replication, making ddGTP a valuable tool in studies involving DNA polymerases and in the development of antiviral therapies. The sodium salt form enhances its solubility in aqueous solutions, facilitating its use in laboratory settings. ddGTP is typically utilized in various applications, including PCR (polymerase chain reaction), Sanger sequencing, and as a substrate in enzymatic reactions. Its ability to terminate DNA chain elongation allows researchers to analyze DNA sequences with precision. As a chemical substance, ddGTP is generally handled with care, following standard laboratory safety protocols due to its biochemical activity.
Formula:C10H16N5O12P3
InChI:InChI=1/C10H16N5O12P3/c11-10-13-8-7(9(16)14-10)12-4-15(8)6-2-1-5(25-6)3-24-29(20,21)27-30(22,23)26-28(17,18)19/h4-6H,1-3H2,(H,20,21)(H,22,23)(H2,17,18,19)(H3,11,13,14,16)/t5-,6+/m0/s1
Synonyms:
  • 2,3-Dideoxyguanosine-5-triphosphoric acid = ddGTP
  • triphosphoric acid, mono[[(5R)-5-(2-amino-3,6-dihydro-6-oxo-9H-purin-9-yl)tetrahydro-2-furanyl]methyl] ester
  • triphosphoric acid, mono[[(2S,5R)-5-(2-amino-3,6-dihydro-6-oxo-9H-purin-9-yl)tetrahydro-2-furanyl]methyl] ester
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