CAS 6877-32-3

Corynoxine

Description:

Corynoxine is an alkaloid derived from the plant species of the genus Corynanthe, particularly Corynanthe johimbe. It is known for its complex structure, which includes a tetracyclic framework. Corynoxine exhibits psychoactive properties and has been studied for its potential effects on the central nervous system. The compound is often associated with stimulant and analgesic activities, making it of interest in pharmacological research. Its mechanism of action may involve interactions with neurotransmitter systems, although specific pathways are still under investigation. Corynoxine is typically found in low concentrations in the plant material, necessitating extraction and purification for study. As with many alkaloids, it may exhibit toxicity at higher doses, and its safety profile is an important consideration in any therapeutic context. Additionally, the compound's solubility and stability can vary depending on environmental conditions, which can influence its bioavailability and efficacy in biological systems. Overall, Corynoxine represents a fascinating subject for further research in both medicinal chemistry and pharmacology.

Formula: C₂₂H₂₈N₂O₄

InChI: InChI=1S/C22H28N2O4/c1-4-14-12-24-10-9-22(17-7-5-6-8-18(17)23-21(22)26)19(24)11-15(14)16(13-27-2)20(25)28-3/h5-8,13-15,19H,4,9-12H2,1-3H3,(H,23,26)/b16-13+/t14-,15+,19+,22+/m1/s1

InChI key: InChIKey=DAXYUDFNWXHGBE-NRAMRBJXSA-N

SMILES: O=C1[C@]2([C@]3(N(CC2)C[C@@H](CC)[C@@H](\C(\C(OC)=O)=C/OC)C3)[H])C=4C(N1)=CC=CC4

Synonyms:

• Corynoxan-16-carboxylic acid, 16,17-didehydro-17-methoxy-2-oxo-, methyl ester, (16E)-
• Methyl (16E)-16-(methoxymethylene)-2-oxocorynoxan-17-oate
• Spiro[3H-indole-3,1′(5′H)-indolizine]-7′-acetic acid, 6′-ethyl-1,2,2′,3′,6′,7′,8′,8′a-octahydro-α-(methoxymethylene)-2-oxo-, methyl ester, (αE,1′S,6′S,7′S,8′aS)-
• Spiro[3H-indole-3,1′(5′H)-indolizine]-7′-acetic acid, 6′-ethyl-1,2,2′,3′,6′,7′,8′,8′a-octahydro-α-(methoxymethylene)-2-oxo-, methyl ester, [1′S-[1′α,6′β,7′β(E),8′aα]]-
• spiro[3H-indole-3,1'(5'H)-indolizine]-7'-acetic acid, 6'-ethyl-1,2,2',3',6',7',8',8'a-octahydro-alpha-(methoxymethylene)-2-oxo-, methyl ester, (alphaE,3S,6'S,7'S,8'aS)-
• Corynoxine

Methyl (E)-2-((3S,6'S,7'S,8a'S)-6'-ethyl-2-oxo-2',3',6',7',8',8a'-hexahydro-5'H-spiro[indoline-3,1'-indolizin]-7'-yl)-3-methoxyacrylate

CAS: 6877-32-3

Formula: C₂₂H₂₈N₂O₄

Purity: 98%

Molecular weight: 384.4687

Ref: IN-DA00FC1H

Corynoxine

CAS: 6877-32-3

Corynoxine

Purity: ≥95%

Molecular weight: 384.47g/mol

Ref: 54-BUP04674

Corynoxine

CAS: 6877-32-3

Formula: C₂₂H₂₈N₂O₄

Molecular weight: 384.48

Ref: 7W-GY9425

Corynoxine

CAS: 6877-32-3

Formula: C₂₂H₂₈N₂O₄

Purity: 95%~99%

Molecular weight: 384.476

Ref: BP-BP0400

Corynoxine

CAS: 6877-32-3

Corynoxine is a tetracyclic oxindole alkaloid isolated from Uncaria macrophylla.

Formula: C₂₂H₂₈N₂O₄

Purity: 96.83% - 99.93%

Color and Shape: Solid

Molecular weight: 384.47

Ref: TM-T5S0658

Corynoxine

CAS: 6877-32-3

Formula: C₂₂H₂₈N₂O₄

Molecular weight: 384.48

Ref: 4Z-C-503001

Corynoxine

CAS: 6877-32-3

Corynoxine is an autophagy-enhancing compound, which is derived from the traditional Chinese medicinal plant Uncaria rhynchophylla. As an oxindole alkaloid, it acts by modulating intracellular signaling pathways to promote autophagy, the cellular degradation and recycling process essential for maintaining cellular homeostasis. Corynoxine's mode of action involves the upregulation of autophagic flux, potentially through the inhibition of mTOR signaling, which is a central regulator of cell growth and metabolism.

Formula: C₂₂H₂₈N₂O₄

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 384.5 g/mol

Ref: 3D-FC74140