CAS 6890-08-0

2-hydroxyisoquinoline-1,3(2H,4H)-dione

Description:

2-Hydroxyisoquinoline-1,3(2H,4H)-dione, also known as 2-hydroxy-1,3-dihydroisoquinoline-1,3-dione, is an organic compound characterized by its isoquinoline structure, which features a fused bicyclic system. This compound contains a hydroxyl group (-OH) and two carbonyl groups (C=O) within its molecular framework, contributing to its reactivity and potential biological activity. It typically appears as a solid at room temperature and is soluble in polar solvents, reflecting its ability to engage in hydrogen bonding due to the presence of the hydroxyl group. The compound is of interest in medicinal chemistry and may exhibit various pharmacological properties, including antimicrobial and anti-inflammatory activities. Its structure allows for potential interactions with biological targets, making it a subject of research in drug development. As with many organic compounds, handling should be done with care, considering safety data and potential hazards associated with its use.

Formula: C₉H₇NO₃

InChI: InChI=1/C9H7NO3/c11-8-5-6-3-1-2-4-7(6)9(12)10(8)13/h1-4,13H,5H2

SMILES: c1ccc2c(c1)CC(=O)N(C2=O)O

Synonyms:

• 1,3(2H,4H)-Isoquinolinedione, 2-hydroxy-
• 2-Hydroxyisoquinoline-1,3(2H,4H)-dione

2-Hydroxyisoquinoline-1,3(2H,4H)-dione

CAS: 6890-08-0

Formula: C₉H₇NO₃

Purity: 95%

Color and Shape: Solid

Molecular weight: 177.1568

Ref: IN-DA00FDF9

2-Hydroxyisoquinoline-1,3(2H,4H)-dione

CAS: 6890-08-0

2-Hydroxyisoquinoline-1,3(2H,4H)-dione

Purity: 95%

Ref: 54-OR1041975

2-Hydroxyisoquinoline-1,3(2H,4H)-dione

Controlled Product

CAS: 6890-08-0

Applications 2-Hydroxyisoquinoline-1,3(2H,4H)-dione was recently discovered as a scaffold for the inhibition of HIV-1 integrase and the RNase H function of HIV-1 reverse transcriptase. Its interaction with Mg2+ and Mn2+ was investigated using different spectroscopic techniques and it was reported that 2-hydroxyisoquinoline-1,3(2H,4H)-dione forms a 1:1 complex with Mg2+ but a 1:2 complex with Mn2+. Antiviral agent.
References Greenwald, J., et al.: Biochemistry, 38, 8892 (1999), Tramontano, E., et al.: Antiviral Res., 65, 117 (2005), Schultz, S., et al.: Virus Res., 134, 86 (2008), Williams, P., et al.: Bioorg. Med. Chem. Lett., 22, 6754 (2010),

Formula: C₉H₇NO₃

Color and Shape: Neat

Molecular weight: 177.16

Ref: TR-H939800

2-Hydroxyisoquinoline-1,3(2H,4H)-dione

CAS: 6890-08-0

2-Hydroxyisoquinoline-1,3(2H,4H)-dione (2HIQ) is a potent anti-viral agent that has been shown to inhibit the replication of viruses in cell cultures. 2HIQ inhibits viral replication by binding to the enzyme reverse transcriptase and inhibiting its ability to synthesize DNA from RNA. This drug also has inhibitory properties against human immunodeficiency virus type 1 (HIV-1) and hepatitis C virus (HCV). 2HIQ binds to the active site of the enzyme HIV reverse transcriptase, which is a key enzyme in viral replication. It also binds to HCV NS5B polymerase, which is an essential protein in HCV replication. These interactions lead to inhibition of viral replication and thus prevention of disease progression.

Formula: C₉H₇NO₃

Purity: Min. 95%

Color and Shape: Off-White To Brown Solid

Molecular weight: 177.16 g/mol

Ref: 3D-FH24374

2-Hydroxyisoquinoline-1,3(2H,4H)-dione

CAS: 6890-08-0

Formula: C₉H₇NO₃

Purity: 95%

Color and Shape: Solid

Molecular weight: 177.159

Ref: 10-F244686