CAS 689284-12-6

TAPI 2

CAS: 689284-12-6

ADAM-17 inhibitor with Ki of 120 nM, enhances 5-FU lethality in cancer stem cells, prevents TNF-α release.

Formula: C₁₉H₃₇N₅O₅

Purity: 98%

Color and Shape: Solid

Molecular weight: 415.54

Ref: TM-TP2108

TAPI-2 acetate salt

CAS: 689284-12-6

TAPI-2 is an inhibitor of ADAM-17 (also called TACE) and matrix metalloproteinases (MMPs). It acts as a broad-spectrum inhibitor of these enzymes. TAPI-2 prevents the shedding of tumor necrosis factor-alpha (TNF-α) from cell membranes and can sensitize cancer stem cells to the effects of chemotherapy such as 5-fluorouracil (5-FU) in vitro. It also blocks the phorbol ester-induced shedding of other cell surface proteins like TGF-α and β-amyloid precursor protein.

Formula: C₁₉H₃₇N₅O₅

Purity: Min. 95%

Molecular weight: 415.53 g/mol

Ref: 3D-INH-3852-PI

TAPI 2

CAS: 689284-12-6

TAPI-2 is an inhibitor of ADAM-17 (also called TACE) and matrix metalloproteinases (MMPs). It acts as a broad-spectrum inhibitor of these enzymes. TAPI-2 prevents the shedding of tumor necrosis factor-alpha (TNF-α) from cell membranes and can sensitize cancer stem cells to the effects of chemotherapy such as 5-fluorouracil (5-FU) in vitro. It also blocks the phorbol ester-induced shedding of other cell surface proteins like TGF-α and β-amyloid precursor protein.

Formula: C₁₉H₃₇N₅O₅

Purity: Min. 95%

Molecular weight: 415.54 g/mol

Ref: 3D-PCB28412