CAS 689293-68-3
:Ceftolozane
Description:
Ceftolozane is a synthetic cephalosporin antibiotic, primarily used to treat infections caused by certain Gram-negative bacteria. It is characterized by its broad-spectrum activity, particularly against Pseudomonas aeruginosa, which is often resistant to many other antibiotics. Ceftolozane works by inhibiting bacterial cell wall synthesis, leading to cell lysis and death. It is often combined with tazobactam, a beta-lactamase inhibitor, to enhance its efficacy against beta-lactamase-producing organisms. The compound is typically administered intravenously and is indicated for complicated urinary tract infections and intra-abdominal infections. Ceftolozane has a favorable pharmacokinetic profile, with good tissue penetration and a relatively long half-life, allowing for less frequent dosing. Its safety profile is generally acceptable, with common side effects including gastrointestinal disturbances and potential allergic reactions. As a newer antibiotic, ceftolozane represents an important option in the ongoing battle against antibiotic resistance, particularly in hospital settings where resistant infections are prevalent.
Formula:C23H30N12O8S2
InChI:InChI=1S/C23H30N12O8S2/c1-23(2,20(40)41)43-31-11(15-30-21(26)45-32-15)16(36)29-12-17(37)35-13(19(38)39)9(8-44-18(12)35)6-34-7-10(14(25)33(34)3)28-22(42)27-5-4-24/h7,12,18,25H,4-6,8,24H2,1-3H3,(H7,26,27,28,29,30,32,36,38,39,40,41,42)/b31-11-/t12-,18-/m1/s1
InChI key:InChIKey=JHFNIHVVXRKLEF-DCZLAGFPSA-N
SMILES:C([O-])(=O)C=1N2[C@@]([C@H](NC(/C(=N\OC(C(O)=O)(C)C)/C3=NSC(N)=N3)=O)C2=O)(SCC1C[N+]4=CC(NC(NCCN)=O)=C(N)N4C)[H]
Synonyms:- 1H-Pyrazolium, 5-amino-4-[[[(2-aminoethyl)amino]carbonyl]amino]-2-[[(6R,7R)-7-[[(2Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-[(1-carboxy-1-methylethoxy)imino]acetyl]amino]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]-1-methyl-, inner salt
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Ceftolozane
CAS:Ceftolozane (FR-264,205 or CXA-101) is a cephalosporin antibiotic for drug-resistant gram-negative and gram-positive infections, used with tazobactam.Formula:C23H30N12O8S2Color and Shape:SolidMolecular weight:666.69
