CAS 68941-95-7

5-fluorouracil-15N2

Description:

5-Fluorouracil-15N2 is a modified form of the chemotherapeutic agent 5-fluorouracil (5-FU), which is primarily used in the treatment of various cancers, including colorectal, breast, and head and neck cancers. The incorporation of nitrogen-15 (15N) isotopes in its structure allows for specific applications in research, particularly in metabolic studies and tracer experiments. This compound functions as an antimetabolite, inhibiting the enzyme thymidylate synthase, which is crucial for DNA synthesis and repair. The presence of the fluorine atom enhances its ability to interfere with nucleic acid metabolism. As a nitrogen-labeled compound, 5-fluorouracil-15N2 can be utilized in studies involving pharmacokinetics and drug metabolism, providing insights into the drug's behavior in biological systems. Its chemical properties, such as solubility and stability, are similar to those of 5-fluorouracil, but the isotopic labeling may affect its interactions and bioavailability. Overall, 5-fluorouracil-15N2 serves as a valuable tool in both clinical and research settings.

Formula: C₄H₃FN₂O₂

5-Fluorouracil-15N2

CAS: 68941-95-7

5-Fluorouracil-15N2 is a nitrogen-15 labeled form of 5-Fluorouracil (5-FU), a uracil analog (nucleoside antimetabolite/analog) and potent antitumor agent. It hampers pyrimidine synthesis by inhibiting thymidylate synthase, depleting the intracellular dTTP pool, inducing apoptosis, acting as a chemotherapeutic sensitizer, inhibiting HIV, and damaging exosome-specific rRNA.

Formula: C₄H₃FN₂O₂

Color and Shape: Solid

Molecular weight: 132.06

Ref: TM-TMID-1032

5-Fluorouracil-15N2

CAS: 68941-95-7

Purity: 98 atom % 15N

Color and Shape: White Solid

Molecular weight: 132.10

Ref: 3U-N2140

5-Fluorouracil-15N2

CAS: 68941-95-7

Applications 5-Fluorouracil-15N2 (CAS# 68941-95-7) is a useful isotopically labeled research compound. This compound can be used for isotopic analysis by gas chromatography-mass spectroscopy for various pyrimidine metabolites and antimetabolites.
References Schwandt, H.J.et.al., Nucleic Acid Chem, 2,901-915,(1978);

Formula: C₄H₃FN)₂O₂

Color and Shape: Neat

Molecular weight: 132.06

Ref: TR-F596006

5-Fluorouracil-15N2

CAS: 68941-95-7

5-Fluorouracil-15N2 is an anticancer drug that acts as a potent inhibitor of kinases involved in cell division and proliferation. It is used to treat various types of cancer, including breast, colon, and prostate cancer. This drug works by interfering with the synthesis of DNA and RNA, leading to the inhibition of protein synthesis and ultimately inducing apoptosis in cancer cells. 5-Fluorouracil-15N2 has been shown to be effective against human cancer cell lines in vitro as well as in vivo tumor models. This medicinal analog can be detected in urine samples after administration and has been studied for its potential use as a biomarker for monitoring cancer therapy. Additionally, recent studies have shown that 5-Fluorouracil-15N2 may have anti-tumor effects in Chinese hamster ovary cells by inhibiting protein kinase C activity.

Formula: C₄H₃FN₂O₂

Purity: Min. 95%

Molecular weight: 132.06 g/mol

Ref: 3D-TCA94195