CAS 69-05-6

Quinacrine dihydrochloride

Description:

Quinacrine dihydrochloride, with the CAS number 69-05-6, is a synthetic compound that belongs to the class of acridine derivatives. It is primarily known for its use as an antimalarial agent and has also been utilized in various research applications, including as a fluorescent dye and in the study of cellular processes. The substance appears as a yellow crystalline powder and is soluble in water, which facilitates its use in biological studies. Quinacrine dihydrochloride exhibits a range of biological activities, including potential antiviral and anticancer properties. Its mechanism of action is thought to involve intercalation into DNA, leading to disruption of nucleic acid functions. However, it is important to note that quinacrine can have side effects, and its use has declined with the advent of more effective antimalarial drugs. Safety precautions should be observed when handling this compound, as it may pose health risks if not managed properly.

Formula: C₂₃H₃₀ClN₃O·2ClH

InChI: InChI=1S/C23H30ClN3O.2ClH/c1-5-27(6-2)13-7-8-16(3)25-23-19-11-9-17(24)14-22(19)26-21-12-10-18(28-4)15-20(21)23;;/h9-12,14-16H,5-8,13H2,1-4H3,(H,25,26);2*1H

InChI key: InChIKey=UDKVBVICMUEIKS-UHFFFAOYSA-N

SMILES: N(C(CCCN(CC)CC)C)C=1C2=C(N=C3C1C=CC(Cl)=C3)C=CC(OC)=C2.Cl

Synonyms:

• Acridine, 6-chloro-9-[[4-(diethylamino)-1-methylbutyl]amino]-2-methoxy-, dihydrochloride
• 866RP
• SN 390
• 1,4-Pentanediamine, N4-(6-chloro-2-methoxy-9-acridinyl)-N1,N1-diethyl-, dihydrochloride
• 1,4-Pentanediamine, N4-(6-chloro-2-methoxy-9-acridinyl)-N1,N1-diethyl-, hydrochloride (1:2)

2-Methoxy-6-chloro-9-(4-diethylamino-1-methylbutylamino)acridine dihydrochloride

CAS: 69-05-6

Formula: C₂₃H₃₂Cl₃N₃O

Purity: 90%

Color and Shape: Solid

Molecular weight: 472.8787

Ref: IN-DA0035K4

Quinacrine dihydrochloride

CAS: 69-05-6

Quinacrine dihydrochloride (Mepacrine dihydrochloride) is the dihydrochloride salt of the 9-aminoacridine derivative quinacrine with potential antineoplastic

Formula: C₂₃H₃₀CLN₃O·2HCl

Purity: 98.24% - 99.80%

Color and Shape: Yellow Crystals Or Powder

Molecular weight: 472.88

Ref: TM-T0942

N4-(6-Chloro-2-Methoxyacridin-9-Yl)-N1,N1-Diethylpentane-1,4-Diamine Dihydrochloride

CAS: 69-05-6

N4-(6-Chloro-2-Methoxyacridin-9-Yl)-N1,N1-Diethylpentane-1,4-Diamine Dihydrochloride

Purity: 98%

Molecular weight: 472.88g/mol

Ref: 54-OR1029504

Quinacrine dihydrochloride

CAS: 69-05-6

Quinacrine dihydrochloride

Purity: ≥98%

Molecular weight: 472.88g/mol

Ref: 54-BUP17411

Quinacrine dihydrochloride

CAS: 69-05-6

Formula: C₂₃H₃₀ClN₃O·2HCl

Purity: (HPLC) ≥ 97.0%

Color and Shape: Off-white to light yellow powder

Molecular weight: 472.88

Ref: 7W-GL0169

Mepacrine Hydrochloride

Controlled Product

CAS: 69-05-6

Formula: C₂₃H₃₀ClN₃OClH

Color and Shape: Neat

Molecular weight: 472.88

Ref: 86-MM1695.00

Quinacrine Dihydrochloride

Controlled Product

CAS: 69-05-6

Stability Hygroscopic
Applications Quinacrine 2HCl is a lipophilic cationic drug with multiple actions that is commonly used as an anti-protozoal agent. It is a non-selective MAO-A/B inhibitor.
References Bockelmann, S., et al.: J. Biol. Chem., 285, 38304 (2010); Wrench, A., et al.: PLoS ONE, 8, e54498 (2013); Kasymov, V., et al.: J. Neuroscience, 33, 435 (2013); Mori, T., et al.: Biol. Pharm. Bull., 35, 2243 (2012)

Formula: C₂₃H₃₀ClN₃O·2ClH

Color and Shape: Neat

Molecular weight: 472.88

Ref: TR-Q550610

6-Chloro-9-[[4-(diethylamino)-1-methylbutyl]amino]-2-methoxyacridine dihydrochloride

CAS: 69-05-6

6-Chloro-9-[[4-(diethylamino)-1-methylbutyl]amino]-2-methoxyacridine dihydrochloride (CMA) is a fluorescent dye that is used in the diagnosis of platelet disorders. It binds to the beta subunit of glycoprotein IIb/IIIa receptors on platelets, which are involved in the aggregation of platelets. CMA has shown to be effective against antibiotic resistant strains and may be useful for patients with infectious diseases. This drug has been shown to have cytosolic calcium ion (Ca2+) antagonist properties and an inhibitory effect on cell nuclei, as well as biological properties similar to mepacrine and atabrine.

Formula: C₂₃H₃₀ClN₃O•(HCl)₂

Purity: Min. 98 Area-%

Color and Shape: Slightly Yellow Powder

Molecular weight: 472.88 g/mol

Ref: 3D-FC76313