CAS 69-22-7

Caffeine citrate

Description:

Caffeine citrate is a chemical compound that combines caffeine, a central nervous system stimulant, with citric acid. It is primarily used in medical settings, particularly for the treatment of apnea in premature infants, as it helps stimulate breathing. Caffeine citrate is a white to off-white crystalline powder that is soluble in water, which facilitates its administration in clinical environments. The compound exhibits the stimulant properties of caffeine, promoting alertness and reducing fatigue. Its pharmacokinetics involve rapid absorption and metabolism in the liver, leading to increased plasma concentrations of caffeine. The citrate component enhances the solubility and bioavailability of caffeine, making it more effective for therapeutic use. Caffeine citrate is generally well-tolerated, but potential side effects may include increased heart rate, gastrointestinal disturbances, and nervousness, particularly at higher doses. As with any medication, it is important to use caffeine citrate under medical supervision to ensure safety and efficacy.

Formula: C₁₄H₁₈N₄O₉

InChI: InChI=1/C8H10N4O2.C6H8O7/c1-10-4-9-6-5(10)7(13)12(3)8(14)11(6)2;7-3(8)1-6(13,5(11)12)2-4(9)10/h4H,1-3H3;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)

InChI key: InChIKey=RCQXSQPPHJPGOF-UHFFFAOYSA-N

SMILES: C(CC(O)=O)(CC(O)=O)(C(O)=O)O.O=C1C2=C(N(C)C(=O)N1C)N=CN2C

Synonyms:

• 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, mixt. with 3,7-dihydro-1,3,7-trimethyl-1H-purine-2,6-dione
• 1H-Purine-2,6-dione, 3,7-dihydro-1,3,7-trimethyl-, mixt. contg.
• 1H-purine-2,6-dione, 3,7-dihydro-1,3,7-trimethyl-, 2-hydroxy-1,2,3-propanetricarboxylate (1:1) (salt)
• Cafcit
• Caffeina citrate
• Caffeine Citrated
• Caffeine citrate
• Caffeine citrate (1:1)
• Caffeine, citrated [USAN]
• Cafnea
• Citrated caffein
• Citrated caffeine
• Citric acid, compd. with caffeine (1:1)
• Gencebok
• Peyona
• 1,3,7-Trimethyl-3,7-dihydro-1H-purine-2,6-dione 2-hydroxypropane-1,2,3-tricarboxylate (1:1)
• 1,3,7-TRIMETHYL-2,6-DIOXOPURINE CITRATE
• 1,3,7-Trimethyl-3,7-dihydro-purin-2,6-dion2-hydroxypropane-1,2,3-tricarboxylic acid,1,3,7-trimethyl
• thyl-1h-purine-2,6-dione
• 1,3,7-TRIMETHYLXANTHINE CITRATE
• Coffeinum-citrate
• citricacid,compd.withcaffeine(1:1)
• caffeinecitrate(1:1)
• CAFFEINE CITRATED GRANULAR
• caffeinacitrate
• Kaffein,Citrat
• COFFEINE CITRATE
• METHYLTHEOBROMINE CITRATE
• Caffeine Citrate USP
• Mixture with citric acid
• CAFFEINE,CITRATED,POWDER,PURIFIED
• GUARANINE CITRATE
• Caffeine, Citrated, Powder
• 2-HYDROXYPROPANE-1,2,3-TRICARBOXYLIC ACID,1,3,7-TRIMETHYLPURINE-2,6-DIONE
• citratedcaffein

Caffeine Citrate

Controlled Product

CAS: 69-22-7

Formula: C₈H₁₀N₄O₂·C₆H₈O₇

Color and Shape: White

Molecular weight: 386.31

Ref: 86-MM1851.00

Caffeine Citrate

CAS: 69-22-7

Formula: C₈H₁₀N₄O₂C₆H₈O₇

Molecular weight: 194.2 : 192.1

Ref: ST-EA-CP-C47008

Caffeine citrate

Controlled Product

CAS: 69-22-7

Caffeine citrate is a low-dose caffeine product that has been shown to increase locomotor activity in rats. Caffeine citrate is an ester of caffeine and citric acid. It inhibits the enzyme that breaks down acetylcholine, which may lead to an increase in brain functions. Caffeine citrate is used as a treatment for apnea in pediatric patients, and it has also been shown to prevent bacterial translocation and reduce liver impairment caused by certain drugs. The therapeutic effect of caffeine citrate may be due to its ability to inhibit mitochondrial membrane potential, or its effects on basic proteins such as sodium citrate, or both.

Formula: C₈H₁₀N₄O₂·C₆H₈O₇

Color and Shape: White Powder

Molecular weight: 386.31 g/mol

Ref: 3D-FC35311

Caffeine Citrate

CAS: 69-22-7

Applications Caffeine citrate (Cafcit) is a citrate salt of Caffeine, sometimes used in medical treatment, including short-term treatment of apnea of prematurity (lack of breathing in premature infants). Caffeine citrate functions in much the same capacity as does caffeine, but takes effect more quickly; its speed of dissociation is faster than that of Caffeine. Caffeine citrate is typically only used to treat severe migraines.
References Zubair, U.M., et al.: Anal. Profiles Drug Subs., 15, 71 (1986); Cherrah, Y., et al.: Biochem. Pharmacol., 37, 1311 (1988); Grillon, C., et al.: Clin. Neurophysiol., 114, 1557 (2003); Duangdao, D., et al.: Behav. Brain Res., 205, 1 (2009);

Formula: C₈H₁₀N₄O₂·C₆H₈O₇

Color and Shape: White

Molecular weight: 386.31

Ref: TR-C080115

Caffeine Citrate

CAS: 69-22-7

Color and Shape: Neat

Ref: 61-FOR1851.00