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CAS 69-44-3

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Amodiaquine hydrochloride

Description:
Amodiaquine hydrochloride is an antimalarial compound that belongs to the 4-aminoquinoline class of drugs. It is primarily used in the treatment and prevention of malaria, particularly in areas where resistance to other antimalarial medications is prevalent. The substance appears as a white to off-white crystalline powder and is soluble in water, which facilitates its administration in aqueous solutions. Its mechanism of action involves the inhibition of heme polymerization, leading to the accumulation of toxic heme in the malaria parasite. Amodiaquine hydrochloride has a relatively long half-life, allowing for once-daily dosing in some treatment regimens. However, it is associated with potential side effects, including hepatotoxicity and agranulocytosis, necessitating careful monitoring during use. Additionally, it may interact with other medications, so a thorough review of a patient's medication history is essential before prescribing. Overall, while effective against malaria, the use of amodiaquine hydrochloride requires consideration of its safety profile and potential drug interactions.
Formula:C20H22ClN3O·2ClH
InChI:InChI=1S/C20H22ClN3O.2ClH/c1-3-24(4-2)13-14-11-16(6-8-20(14)25)23-18-9-10-22-19-12-15(21)5-7-17(18)19;;/h5-12,25H,3-4,13H2,1-2H3,(H,22,23);2*1H
InChI key:InChIKey=ROEBJVHPINPMKL-UHFFFAOYSA-N
SMILES:N(C=1C2=C(C=C(Cl)C=C2)N=CC1)C3=CC(CN(CC)CC)=C(O)C=C3.Cl
Synonyms:
  • 4-(7-Chloro-4-quinolylamino)-α-(diethylamino)-o-cresol dihydrochloride
  • 7-Chloro-4-(3′-diethylaminomethyl-4′-hydroxyanilino)quinoline dihydrochloride
  • Acrichin dihydrochloride
  • Amodiaquin dihydrochloride
  • Amodiaquine dihydrochloride
  • Basoquine
  • Camoquin hydrochloride
  • Phenol, 4-[(7-chloro-4-quinolinyl)amino]-2-[(diethylamino)methyl]-, dihydrochloride
  • Phenol, 4-[(7-chloro-4-quinolinyl)amino]-2-[(diethylamino)methyl]-, hydrochloride (1:2)
  • o-Cresol, 4-[(7-chloro-4-quinolyl)amino]-α-(diethylamino)-, dihydrochloride
  • See more synonyms
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