CAS 69014-14-8

Tiotidine

Description:

Tiotidine is a chemical compound classified as a histamine H2 receptor antagonist, primarily used in the treatment of gastrointestinal disorders such as peptic ulcers and gastroesophageal reflux disease (GERD). It functions by inhibiting the action of histamine at the H2 receptors in the stomach lining, thereby reducing gastric acid secretion. Tiotidine is known for its ability to promote healing of the gastric mucosa and alleviate symptoms associated with excessive stomach acid. The compound has a relatively low solubility in water, which can affect its bioavailability and absorption in the gastrointestinal tract. Its pharmacokinetics involve hepatic metabolism and renal excretion. While it has been effective in clinical settings, tiotidine has largely been replaced by other H2 antagonists due to concerns regarding side effects and drug interactions. As with any medication, it is essential to consider potential adverse effects, contraindications, and interactions with other drugs when prescribing or using tiotidine.

Formula: C₁₀H₁₆N₈S₂

InChI: InChI=1/C10H16N8S2/c1-14-9(16-6-11)15-2-3-19-4-7-5-20-10(17-7)18-8(12)13/h5H,2-4H2,1H3,(H2,14,15,16)(H4,12,13,17,18)

InChI key: InChIKey=YDDXVAXDYKBWDX-UHFFFAOYSA-N

SMILES: C(SCCN=C(NC#N)NC)C=1N=C(NC(=N)N)SC1

Synonyms:

• 1-Cyano-3-{2-[({2-[(Diaminomethylidene)Amino]-1,3-Thiazol-4-Yl}Methyl)Sulfanyl]Ethyl}-2-Methylguanidine
• 2-Cyano-1-(2-(((2-((diaminomethylene)amino)-4-thiazolyl)methyl)thio)ethyl)-3-methylguanidine
• Guanidine, N'-cyano-N-(2-(((2-((diaminomethylene)amino)-4-thiazolyl)methyl)thio)ethyl)-N'-methyl-
• Guanidine, N-[2-[[[2-[(aminoiminomethyl)amino]-4-thiazolyl]methyl]thio]ethyl]-N′-cyano-N′′-methyl-
• Ici 125211
• N-(2-(((2-((Aminoiminomethyl)amino)-4-thiazoyl)methyl)thio)ethyl)-N'-cyano-N''-methylguanidine
• N-[2-[[[2-[(Aminoiminomethyl)amino]-4-thiazolyl]methyl]thio]ethyl]-N′-cyano-N′′-methylguanidine
• Tiotidina
• Tiotidina [INN-Spanish]
• Tiotidine [USAN:INN]
• Tiotidinum
• Tiotidinum [INN-Latin]
• Unii-Ezu9Aiz69M
• Tiotidine
• Tiotidine
• 1-cyano-3-[2-[[2-(diaminomethylideneamino)-1,3-thiazol-4-yl]methylsulfanyl]ethyl]-2-methylguanidine
• 1-cyano-3-[2-[(2-guanidinothiazol-4-yl)methylthio]ethyl]-2-methyl-guanidine
• N'-Cyano-N-[2-[[[2-[(aminoiminomethyl)amino]-4-thiazolyl]methyl]thio]ethyl]-N''-methylguanidine
• 1-Methyl-2-cyano-3-[2-[[2-(diaminomethyleneamino)thiazole-4-yl]methylthio]ethyl]guanidine
• 1-Methyl-2-cyano-3-[2-[2-(diaminomethyleneamino)thiazole-4-ylmethylthio]ethyl]guanidine

Tiotidine

CAS: 69014-14-8

Tiotidine is a selective histamine H2-receptor antagonist (pA2=7.3-7.8 for guinea-pig right atrium).

Formula: C₁₀H₁₆N₈S₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 312.42

Ref: TM-T13163