CAS 69056-38-8

Sapropterin dihydrochloride

Description:

Sapropterin dihydrochloride is a synthetic form of the naturally occurring cofactor tetrahydrobiopterin (BH4), primarily used in the treatment of phenylketonuria (PKU), a metabolic disorder characterized by the inability to metabolize phenylalanine. This compound acts as a pharmacological chaperone, enhancing the activity of phenylalanine hydroxylase, the enzyme responsible for converting phenylalanine to tyrosine. Sapropterin dihydrochloride is a white to off-white crystalline powder that is soluble in water, making it suitable for oral administration. Its chemical formula reflects its dihydrochloride salt form, which contributes to its stability and solubility. The substance is generally well-tolerated, with common side effects including headache, gastrointestinal disturbances, and allergic reactions. As a therapeutic agent, it plays a crucial role in managing blood phenylalanine levels, thereby preventing the neurological complications associated with PKU. Its use is typically monitored through regular blood tests to ensure efficacy and safety in patients.

Formula: C₉H₁₅N₅O₃·2ClH

InChI: InChI=1S/C9H15N5O3.2ClH/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7;;/h3-4,6,12,15-16H,2H2,1H3,(H4,10,11,13,14,17);2*1H/t3-,4+,6-;;/m0../s1

InChI key: InChIKey=RKSUYBCOVNCALL-NTVURLEBSA-N

SMILES: O=C1C2=C(NC[C@]([C@H]([C@H](C)O)O)(N2)[H])NC(N)=N1.Cl

Synonyms:

• (6R)-2-Amino-6-((1R,2S)-1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4(1H)-pteridinone dihydrochloride
• (6R)-2-amino-6-[(1R,2S)-1,2-dihydroxypropyl]-5,6,7,8-tetrahydropteridin-4(1H)-one dihydrochloride
• (6R)-5,6,7,8-Tetrahydro-L-Biopterin Dihydrochloride
• (6R)-Tetrahydrobiopterin hydrochloride
• (6β)-5,6,7,8-Tetrahydro-<span class="text-smallcaps">L</span>-biopterin dihydrochloride
• 2-amino-6-[(2S)-1,2-dihydroxypropyl]-5,6,7,8-tetrahydropteridin-4(1H)-one dihydrochloride
• 4(1H)-Pteridinone, 2-amino-6-(1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-, dihydrochloride, [6R-[6R*(1R*,2S*)]]-
• 4(1H)-Pteridinone, 2-amino-6-[(1R,2S)-1,2-dihydroxypropyl]-5,6,7,8-tetrahydro-, dihydrochloride, (6R)-
• 4(1H)-Pteridinone, 5,6,7,8-tetrahydro-2-amino-6-(1,2-dihydroxypropyl)-, dihydrochloride, (6R-(6R*(1R*,2S*)))-
• 4(3H)-Pteridinone, 2-amino-6-[(1R,2S)-1,2-dihydroxypropyl]-5,6,7,8-tetrahydro-, hydrochloride (1:2), (6R)-
• BioMarin T 1401
• Biopten
• Kuvan
• Sapropterin HCl
• Sapropterin hydrochloride
• Shiratori SN 0588
• Sun 0588
• T1401
• Unii-Rg277Lf5B3
• Sapropterin dihydrochloride

(6R)-5,6,7,8-Tetrahydro-l-biopterin diHCl

CAS: 69056-38-8

Formula: C₉H₁₇Cl₂N₅O₃

Purity: 95%

Color and Shape: Solid

Molecular weight: 314.1690

Ref: IN-DA005LS6

Sapropterin dihydrochloride

CAS: 69056-38-8

Sapropterin dihydrochloride

Purity: ≥98%

Molecular weight: 314.17g/mol

Ref: 54-BUP14430

Sapropterin DiHCl (Dehydro Sepiapterin DiHCl)

CAS: 69056-38-8

Formula: C₉H₁₅N₅O₃·2HCl

Color and Shape: White To Off-White Solid

Molecular weight: 241.25 2*36.46

Ref: 4Z-S-311

Sapropterin dihydrochloride

CAS: 69056-38-8

Sapropterin dihydrochloride (6R-BH4 dihydrochloride) is phenylalanine hydroxylase agonist that is approved for the treatment of BH4 responsive PKU.

Formula: C₉H₁₇Cl₂N₅O₃

Purity: 98% - 99.88%

Color and Shape: White Crystalline Solid

Molecular weight: 314.17

Ref: TM-T7117

(6R)-5,6,7,8-Tetrahydrobiopterin Dihydrochloride

CAS: 69056-38-8

Stability Hygroscopic
Applications Tetrahydrobiopterin is a naturally occurring essential cofactor of the three aromatic amino acid hydroxylase enzymes, used in the degradation of amino acid phenylalanine and in the biosynthesis of the neurotransmitters serotonin, melatonin, dopamine, norepinephrine , epinephrine, and is a cofactor for the production of nitric oxide by the nitric oxide synthases. Chemically, its structure is that of a reduced pteridine derivative.
References Levy, Harvey L., et al.: Lancet,  370, 504 (2007); Isojima, Yasushi., et al.: Proc Natl Acad Sci USA .,106, 15744 (2009); Burton, B. K., et al.: J. Inherit. Metab. Dis., 30, 700 (2007)

Formula: C₉H₁₅N₅O₃·2(HCl)

Color and Shape: White To Off-White

Molecular weight: 241.25 + 2(36.46)

Ref: TR-T795613

Sapropterin Dihydrochloride

CAS: 69056-38-8

Formula: C₉H₁₅N₅O₃(HCl)

Molecular weight: 241.3 : 2(36.5)

Ref: ST-EA-CP-S25013

(R)-2-Amino-6-((1R,2S)-1,2-dihydroxypropyl)-5,6,7,8-tetrahydropteridin-4(3H)-one dihydrochloride

CAS: 69056-38-8

Formula: C₉H₁₇Cl₂N₅O₃

Purity: 95%

Molecular weight: 314.17

Ref: 10-F216001

Sapropterin dihydrochloride

CAS: 69056-38-8

Cofactor for nitric oxide synthetase and Phe, Tyr and Trp hydroxylases

Formula: C₉H₁₅N₅O₃·2HCl

Purity: Min. 97 Area-%

Color and Shape: White Powder

Molecular weight: 314.17 g/mol

Ref: 3D-FT04562