CAS 69075-42-9

5-Ethynyl Uridine

Description:

5-Ethynyl Uridine is a modified nucleoside that features an ethynyl group at the 5-position of the uridine base. This structural modification enhances its stability and bioactivity, making it a valuable compound in various biochemical applications, particularly in the field of molecular biology and medicinal chemistry. The presence of the ethynyl group allows for increased resistance to nucleases, which can prolong its half-life in biological systems. 5-Ethynyl Uridine is often utilized in RNA labeling and as a tool for studying RNA synthesis and metabolism. It can be incorporated into RNA molecules during transcription, enabling researchers to track RNA dynamics in living cells. Additionally, this compound has potential therapeutic implications, as it may influence RNA processing and gene expression. Its unique properties make it a subject of interest in the development of antiviral agents and other therapeutic strategies. Overall, 5-Ethynyl Uridine serves as a significant tool in both research and potential clinical applications due to its modified structure and functional capabilities.

Formula: C₁₁H₁₂N₂O₆

Synonyms:

• 5-Ethynyluridine

5-Ethynyl uridine

CAS: 69075-42-9

Formula: C₁₁H₁₂N₂O₆

Purity: 95%

Color and Shape: Solid

Molecular weight: 268.2228

Ref: IN-DA00FBCT

5-Ethynyluridine

CAS: 69075-42-9

5-Ethynyluridine

Purity: ≥98%

Molecular weight: 268.22g/mol

Ref: 54-BUP10668

5-Ethynyluridine

CAS: 69075-42-9

Formula: C₁₁H₁₂N₂O₆

Purity: >95.0%(T)(qNMR)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 268.23

Ref: 3B-E1560

5-Ethynyluridine

CAS: 69075-42-9

5-Ethynyluridine (5-EU) is an uracil analogue functionalized with a terminal alkyne group used for nucleotide, and especially RNA, labelling. 5-EU is cell permeable and is incorporated into RNA during its biosynthesis. The terminal alkyne group in 5-EU can react with azide-functionalised fluorophores or biotine, to form a labelled adduct with a triazole linker.

Formula: C₁₁H₁₂N₂O₆

Purity: Min. 98 Area-%

Color and Shape: Powder

Molecular weight: 268.22 g/mol

Ref: 3D-NE31862

5-Ethynyluridine

CAS: 69075-42-9

Formula: C₁₁H₁₂N₂O₆

Purity: 96%

Color and Shape: Solid

Molecular weight: 268.225

Ref: 10-F463328

5-Ethynyluridine

Controlled Product

CAS: 69075-42-9

Applications 5-Ethynyluridine is used to help detect RNA synthesis in cells by its biosynthetic incorporation into newly transcribed RNA.
References Jao, C., et al.: Proc. Nat. Acad. Sci. U. S. A., 105, 15779 (2008)

Formula: C₁₁H₁₂N₂O₆

Color and Shape: Off-White To Beige

Molecular weight: 268.22

Ref: TR-E932650

5-Ethynyluridine

CAS: 69075-42-9

5-Ethynyluridine marks new RNA for RICK, capturing proteins on various RNAs, even nonpolyadenylated types.

Formula: C₁₁H₁₂N₂O₆

Purity: 99.78%

Color and Shape: Solid

Molecular weight: 268.22

Ref: TM-T36971