CAS 69075-47-4

Cytidine, 2'-deoxy-5-ethynyl-

Description:

Cytidine, 2'-deoxy-5-ethynyl- (CAS 69075-47-4) is a modified nucleoside that features an ethynyl group at the 5-position of the pyrimidine ring, which is a characteristic modification that enhances its properties for various applications, particularly in molecular biology and medicinal chemistry. This compound is a derivative of deoxycytidine, where the ethynyl substitution can influence its interaction with nucleic acids and its incorporation into RNA or DNA. The presence of the ethynyl group can also enhance the stability and binding affinity of the nucleoside, making it useful in the development of antiviral and anticancer agents. Additionally, it may exhibit unique spectroscopic properties due to the triple bond, which can be exploited in various analytical techniques. Overall, 2'-deoxy-5-ethynyl-cytidine serves as a valuable tool in research and therapeutic contexts, particularly in the study of nucleic acid dynamics and the design of nucleoside analogs.

Formula: C₁₁H₁₃N₃O₄

5-Ethynyl-2'-deoxycytidine

CAS: 69075-47-4

Formula: C₁₁H₁₃N₃O₄

Purity: >98.0%(N)

Color and Shape: White to Light yellow to Light orange powder to crystal

Molecular weight: 251.24

Ref: 3B-E1093

Cytidine, 2'-deoxy-5-ethynyl-

CAS: 69075-47-4

Formula: C₁₁H₁₃N₃O₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 251.2386

Ref: IN-DA006DIS

5-Ethynyl-2'-Deoxycytidine

CAS: 69075-47-4

5-Ethynyl-2'-Deoxycytidine

Purity: 98%

Molecular weight: 251.24g/mol

Ref: 54-OR1011871

2'-Deoxy-5-ethynylcytidine

CAS: 69075-47-4

2'-Deoxy-5-ethynylcytidine is a cytosine analog that inhibits the synthesis of viral DNA and the production of new virus particles. It has been shown to inhibit herpes simplex virus type-1 (HSV-1) in cell cultures, as well as other viruses such as vaccinia and adenovirus. 2'-Deoxy-5-ethynylcytidine has also been shown to have anti-cancer properties in animal studies. This drug binds to the cellular nucleic acid, preventing transcription of viral genes into messenger RNA and preventing protein synthesis, thereby inhibiting replication of the virus. 2'-Deoxy-5-ethynylcytidine also inhibits the synthesis of cellular DNA by binding to nuclear DNA.
2'-Deoxy-5-ethynylcytidine is an analog of cytosine that binds to dna polymerase and prevents it from adding on new nucleotides, which blocks viral reproduction.

Formula: C₁₁H₁₃N₃O₄

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 251.24 g/mol

Ref: 3D-ND161709

5′-Ethynyl-2′-deoxycytidine

CAS: 69075-47-4

Purity: 98%

Molecular weight: 251.242

Ref: 10-F842638

5-Ethynyl-2’-deoxycytidine

Controlled Product

CAS: 69075-47-4

Formula: C₁₁H₁₃N₃O₄

Color and Shape: Neat

Molecular weight: 251.239

Ref: TR-E932170

5'-Ethynyl-2'-deoxycytidine

CAS: 69075-47-4

5'-Ethynyl-2'-deoxycytidine (EdC) functions as a nucleoside analog effectively inhibiting the replication of herpes simplex virus-1 (HSV-1) KOS strain with an ID50 of 0.2 μg/mL. Additionally, it decreases virus-induced cytopathogenic effects in PRK cells for HSV-1, HSV-2, and vaccinia virus strains, demonstrating MIC values between 0.2 to 5 μg/mL. EdC acts as a thymidylate synthetase inhibitor, selectively impacting the DNA incorporation rates of [1',2'-3H]deoxyuridine compared to [CH3-3H]deoxythymidine in PRK cells with ID50s of 3 and 120 μg/mL, respectively. It further inhibits thymidine synthetase and curtails L1210 cell proliferation, a process reversible by deoxythymidine (ID50s are 4.4 and 1,000 μg/mL, respectively). Also, EdC is utilized in monitoring DNA synthesis and cellular replication through click chemistry conjugation, linking its ethynyl group with the azido group of various fluorochromes.

Formula: C₁₁H₁₃N₃O₄

Color and Shape: Solid

Molecular weight: 251.242

Ref: TM-T84380