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CAS 69199-40-2

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3'-deoxyuridine 5'-(tetrahydrogen triphosphate)

Description:
3'-Deoxyuridine 5'-(tetrahydrogen triphosphate), commonly referred to as dUTP, is a nucleotide that plays a crucial role in various biochemical processes, particularly in DNA synthesis and repair. It is a derivative of uridine, where the hydroxyl group at the 3' position of the ribose sugar is absent, making it a deoxynucleotide. The triphosphate moiety provides high-energy bonds, which are essential for the incorporation of dUTP into DNA strands during replication. dUTP is also involved in the regulation of nucleotide pools and can be converted to dUMP, which is a precursor for thymidine synthesis. Its structure includes a ribose sugar, a uracil base, and three phosphate groups, contributing to its reactivity and function in enzymatic reactions. Due to its role in cellular metabolism, dUTP is significant in molecular biology applications, including PCR and other DNA manipulation techniques. Additionally, its stability and reactivity make it a valuable tool in research and therapeutic contexts.
Formula:C9H15N2O14P3
InChI:InChI=1/C9H15N2O14P3/c12-6-3-5(23-8(6)11-2-1-7(13)10-9(11)14)4-22-27(18,19)25-28(20,21)24-26(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,20,21)(H,10,13,14)(H2,15,16,17)/t5-,6+,8+/m0/s1
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