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CAS 69304-43-4

:

N-Benzoyl-3′,5′-O-[1,1,3,3-tetrakis(1-methylethyl)-1,3-disiloxanediyl]cytidine

Description:
N-Benzoyl-3′,5′-O-[1,1,3,3-tetrakis(1-methylethyl)-1,3-disiloxanediyl]cytidine is a synthetic nucleoside derivative characterized by the presence of a benzoyl group and a unique siloxane moiety. The compound features a cytidine base, which is a nucleoside composed of a pyrimidine base (cytosine) linked to a ribose sugar. The siloxane component introduces significant steric hindrance and hydrophobic characteristics, which can influence the compound's solubility and stability. This structure may enhance the compound's resistance to enzymatic degradation, making it potentially useful in pharmaceutical applications, particularly in drug delivery systems or as a prodrug. The presence of multiple isopropyl groups in the siloxane chain contributes to its bulky nature, which can affect its interaction with biological targets. Overall, this compound exemplifies the intersection of organic chemistry and medicinal chemistry, showcasing how structural modifications can lead to novel properties and functionalities in nucleoside analogs.
Formula:C28H43N3O7Si2
InChI:InChI=1S/C28H43N3O7Si2/c1-17(2)39(18(3)4)35-16-22-25(37-40(38-39,19(5)6)20(7)8)24(32)27(36-22)31-15-14-23(30-28(31)34)29-26(33)21-12-10-9-11-13-21/h9-15,17-20,22,24-25,27,32H,16H2,1-8H3,(H,29,30,33,34)/t22-,24-,25-,27-/m1/s1
InChI key:InChIKey=NFIAUHQTSCWVMS-LYPBTDJXSA-N
SMILES:O[C@@H]1[C@]2([C@](O[C@H]1N3C(=O)N=C(NC(=O)C4=CC=CC=C4)C=C3)(CO[Si](C(C)C)(C(C)C)O[Si](C(C)C)(C(C)C)O2)[H])[H]
Synonyms:
  • 6H-Furo[3,2-f]-1,3,5,2,4-trioxadisilocin, cytidine deriv.
  • Cytidine, N-benzoyl-3′,5′-O-[1,1,3,3-tetrakis(1-methylethyl)-1,3-disiloxanediyl]-
  • N-Benzoyl-3′,5′-O-[1,1,3,3-tetrakis(1-methylethyl)-1,3-disiloxanediyl]cytidine
  • Cytidine, N-benzoyl-3^,5^-O-[1,1,3,3-tetrakis(1-Methylethyl)-1,3-disiloxanediyl]-
  • 3',5'-TIPS-Bz-rC
  • 3',5'-TIPS-N-Bz-C
  • N4-Benzoyl-3',5'-O-(1,1,3,3-tetraisopropyl-1,3-disiloxanediyl)cytidine &gt
  • N-(1-((6aR,8R,9R,9aS)-9-Hydroxy-2,2,4,4-tetraisopropyltetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)benzamide
  • N4-Benzoyl-3',5'-O-(1,1,3,3-tetraisopropyl-1,3-disiloxanediyl)cytidine
  • 3',5'-TIPS-N-Bz-Cytidine
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