CAS 69304-47-8

Brivudine

Description:

Brivudine is an antiviral medication primarily used for the treatment of herpes zoster, commonly known as shingles. It is a nucleoside analog that specifically inhibits viral DNA synthesis, thereby preventing the replication of the varicella-zoster virus. The chemical structure of Brivudine is characterized by its modified nucleoside framework, which enhances its selectivity and efficacy against the virus. It is typically administered orally and is known for its favorable pharmacokinetic profile, allowing for once-daily dosing. Brivudine is generally well-tolerated, although it may cause side effects such as gastrointestinal disturbances or skin reactions in some patients. Importantly, it should not be used in conjunction with certain other antiviral medications, such as zidovudine, due to potential interactions that can lead to increased toxicity. Overall, Brivudine represents a significant advancement in antiviral therapy, particularly for individuals suffering from herpes zoster, providing an effective option for managing this painful condition.

Formula: C₁₁H₁₃BrN₂O₅

InChI: InChI=1S/C11H13BrN2O5/c12-2-1-6-4-14(11(18)13-10(6)17)9-3-7(16)8(5-15)19-9/h1-2,4,7-9,15-16H,3,5H2,(H,13,17,18)/b2-1+/t7-,8+,9+/m0/s1

InChI key: InChIKey=ODZBBRURCPAEIQ-PIXDULNESA-N

SMILES: O=C1N([C@@H]2O[C@H](CO)[C@@H](O)C2)C=C(/C=C/Br)C(=O)N1

Synonyms:

• (E)-5-(2-Bromovinyl)deoxyuridine
• (E)-5-(2-bromovinyl)-2'-deoxyuridine
• (E)-5-O-(2-bromoethenyl)-2′-deoxyuridine
• 5-[(1E)-2-Bromoethenyl]-2′-deoxyuridine
• 5-[(E)-2-bromoethenyl]-1-(2-deoxy-beta-L-erythro-pentofuranosyl)pyrimidine-2,4(1H,3H)-dione
• 5-[(E)-2-bromoethenyl]-2'-deoxyuridine
• Brivudin
• Bromovinyldeoxyuridine
• E-5-(2-Bromovinyl)-2'-Deoxy-Uridine
• Helpin
• N-(2,6-dichloro-4-{[(2-chloroethyl)(methyl)amino]methyl}phenyl)-4,5-dihydro-1H-imidazol-2-amine dihydrochloride
• Rp 101
• Uridine, 5-(2-bromoethenyl)-2′-deoxy-, (E)-
• Uridine, 5-[(1E)-2-bromoethenyl]-2′-deoxy-

(E)-5-(2-Bromovinyl)-2'-deoxyuridine

CAS: 69304-47-8

Formula: C₁₁H₁₃BrN₂O₅

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 333.14

Ref: 3B-B3404

Brivudine, 98%

CAS: 69304-47-8

It is used as pharmaceutical intermediate. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a

Formula: C₁₁H₁₃BrN₂O₅

Purity: 98%

Color and Shape: Crystalline powder or powder, White to pale cream

Molecular weight: 333.14

Ref: 02-H27853

Brivudine

CAS: 69304-47-8

Formula: C₁₁H₁₃BrN₂O₅

Purity: 98%

Color and Shape: Solid

Molecular weight: 333.1353

Ref: IN-DA003OJV

Brivudine

CAS: 69304-47-8

Brivudine (BVDU), an antiviral medicine, is used in the therapy of herpes zoster.

Formula: C₁₁H₁₃BrN₂O₅

Purity: 99.51% - 99.85%

Color and Shape: Solid

Molecular weight: 333.14

Ref: TM-T0718

Brivudine

CAS: 69304-47-8

Formula: C₁₁H₁₃BrN₂O₅

Color and Shape: White To Off-White Solid

Molecular weight: 333.14

Ref: 4Z-B-087001

Brivudine-13C-15N2

CAS: 69304-47-8

Formula: C₁₀₁₃CH₁₃Br₁₅N₂O₅

Molecular weight: 336.12

Ref: 4Z-B-087007

5-(E)-(2-Bromovinyl)-2''-deoxyuridine

CAS: 69304-47-8

Formula: C₁₁H₁₃BrN₂O₅

Purity: ≥ 98.0%

Color and Shape: White to off-white powder

Molecular weight: 333.14

Ref: 7W-GN2626

(E)-5-(2-Bromovinyl)-2’-Deoxyuridine

CAS: 69304-47-8

(E)-5-(2-Bromovinyl)-2’-Deoxyuridine

Purity: 98%

Molecular weight: 333.14g/mol

Ref: 54-OR1008352

Brivudine

CAS: 69304-47-8

Brivudine

Purity: ≥98%

Molecular weight: 333.14g/mol

Ref: 54-BUP15813

Brivudine (>90%)

CAS: 69304-47-8

Applications Brivudine is a nucloside analog which causes induction of neuronal differentiation in human reporter cell lines and adult stem cells. Anti-Herpes medication.
References Raasch, K. et al.: Chem. Biol. Drug Des., 86, 129 (2015); Coen, N. et al.: Antimicrob. Agents Chemother., 58, 7312 (2014);

Formula: C₁₁H₁₃BrN₂O₅

Color and Shape: Neat

Molecular weight: 333.14

Ref: TR-B677670

Brivudine

CAS: 69304-47-8

Anti-viral; thymidine analogue; DNA plymerase inhibitor

Formula: C₁₁H₁₃BrN₂O₅

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 333.14 g/mol

Ref: 3D-NB03851

Brivudine

CAS: 69304-47-8

Formula: C₁₁H₁₃BrN₂O₅

Purity: ≥98%(HPLC)

Molecular weight: 333.138

Ref: 10-F463475

Brivudine-13C4,15N2

Controlled Product

CAS: 69304-47-8

Formula: C₇C₄H₁₃BrN₂O₅

Color and Shape: Neat

Molecular weight: 339.09

Ref: TR-B677672