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CAS 69304-47-8

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Brivudine

Description:
Brivudine is an antiviral medication primarily used for the treatment of herpes zoster, commonly known as shingles. It is a nucleoside analog that specifically inhibits viral DNA synthesis, thereby preventing the replication of the varicella-zoster virus. The chemical structure of Brivudine is characterized by its modified nucleoside framework, which enhances its selectivity and efficacy against the virus. It is typically administered orally and is known for its favorable pharmacokinetic profile, allowing for once-daily dosing. Brivudine is generally well-tolerated, although it may cause side effects such as gastrointestinal disturbances or skin reactions in some patients. Importantly, it should not be used in conjunction with certain other antiviral medications, such as zidovudine, due to potential interactions that can lead to increased toxicity. Overall, Brivudine represents a significant advancement in antiviral therapy, particularly for individuals suffering from herpes zoster, providing an effective option for managing this painful condition.
Formula:C11H13BrN2O5
InChI:InChI=1S/C11H13BrN2O5/c12-2-1-6-4-14(11(18)13-10(6)17)9-3-7(16)8(5-15)19-9/h1-2,4,7-9,15-16H,3,5H2,(H,13,17,18)/b2-1+/t7-,8+,9+/m0/s1
InChI key:InChIKey=ODZBBRURCPAEIQ-PIXDULNESA-N
SMILES:O=C1N([C@@H]2O[C@H](CO)[C@@H](O)C2)C=C(/C=C/Br)C(=O)N1
Synonyms:
  • (E)-5-(2-Bromovinyl)deoxyuridine
  • (E)-5-(2-bromovinyl)-2'-deoxyuridine
  • (E)-5-O-(2-bromoethenyl)-2′-deoxyuridine
  • 5-[(1E)-2-Bromoethenyl]-2′-deoxyuridine
  • 5-[(E)-2-bromoethenyl]-1-(2-deoxy-beta-L-erythro-pentofuranosyl)pyrimidine-2,4(1H,3H)-dione
  • 5-[(E)-2-bromoethenyl]-2'-deoxyuridine
  • Brivudin
  • Bromovinyldeoxyuridine
  • E-5-(2-Bromovinyl)-2'-Deoxy-Uridine
  • Helpin
  • See more synonyms
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