CAS 69308-37-8

(-)-Baclofen

Description:

(-)-Baclofen is a chemical compound classified as a muscle relaxant and is primarily used in the treatment of spasticity associated with conditions such as multiple sclerosis and spinal cord injuries. It is a derivative of gamma-aminobutyric acid (GABA) and acts as a GABA_B receptor agonist, which helps to inhibit excessive neuronal activity and reduce muscle tone. The compound is typically administered orally or via intrathecal delivery for more severe cases. (-)-Baclofen is characterized by its chiral nature, existing as a single enantiomer, which contributes to its pharmacological effects. It has a relatively low solubility in water but is soluble in organic solvents. Common side effects may include drowsiness, dizziness, and fatigue, and it is important to taper the dosage to avoid withdrawal symptoms. The compound's chemical structure includes a carboxylic acid group and a phenyl ring, contributing to its biological activity and therapeutic efficacy. Overall, (-)-Baclofen is a valuable medication in managing muscle spasticity and improving patient quality of life.

Formula: C₁₀H₁₂ClNO₂

InChI: InChI=1S/C10H12ClNO2/c11-9-3-1-7(2-4-9)8(6-12)5-10(13)14/h1-4,8H,5-6,12H2,(H,13,14)/t8-/m0/s1

InChI key: InChIKey=KPYSYYIEGFHWSV-QMMMGPOBSA-N

SMILES: [C@H](CC(O)=O)(CN)C1=CC=C(Cl)C=C1

Synonyms:

• (-)-Baclofen
• (3R)-4-amino-3-(4-chlorophenyl)butanoic acid
• (R)-4-Amino-3-(4-chlorophenyl)butanoic acid
• (R)-4-Amino-3-(4-chlorophenyl)butyric acid
• (βR)-β-(Aminomethyl)-4-chlorobenzenepropanoic acid
• <span class="text-smallcaps">D</span>-Baclofen
• Agi 006
• Arbaclofen
• Benzeneporopanoic acid, (beta-(aminomethyl)-4-chloro-, (betaR)-
• Benzenepropanoic acid, beta-(aminomethyl)-4-chloro-, (R)-
• Benzenepropanoic acid, β-(aminomethyl)-4-chloro-, (R)-
• Benzenepropanoic acid, β-(aminomethyl)-4-chloro-, (βR)-
• Stx 209
• Unii-Nyu6Utw25B
• l-Baclofen
• R-(-)-Baclofen

(R)-Baclofen

CAS: 69308-37-8

Formula: C₁₀H₁₂ClNO₂

Purity: >95.0%(T)(HPLC)

Color and Shape: White to Almost white powder to crystaline

Molecular weight: 213.66

Ref: 3B-B5102

(R)-4-Amino-3-(4-chlorophenyl)butanoic acid

CAS: 69308-37-8

Formula: C₁₀H₁₂ClNO₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 213.6608

Ref: IN-DA0036TB

(R)-Baclofen

CAS: 69308-37-8

(R)-Baclofen

Purity: 98%

Molecular weight: 213.66g/mol

Ref: 54-OR1023743

(R)-Baclofen

CAS: 69308-37-8

Ref: 7W-GK7408

(R)-Baclofen

CAS: 69308-37-8

Formula: C₁₀H₁₂ClNO₂

Molecular weight: 213.66

Ref: 4Z-B-409

(R)-baclofen

CAS: 69308-37-8

(R)-baclofen

Purity: ≥95%

Molecular weight: 213.66g/mol

Ref: 54-BUP06121

(R)-baclofen

CAS: 69308-37-8

(R)-baclofen (STX209), a derivative of gamma-aminobutyric acid, is commonly utilized for the treatment of spasticity.

Formula: C₁₀H₁₂ClNO₂

Purity: 97.20% - 98.94%

Color and Shape: Solid

Molecular weight: 213.66

Ref: TM-T6355

(R)-Baclofen

Controlled Product

CAS: 69308-37-8

Applications (R)-Baclofen is the R-Enantiomer of Baclofen, a specific GABA-B receptor agonist and a muscle relaxant (1,2).
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References (1) Brogden, R.N., et al.: Drugs, 8,1 (1974) (2) Song, Y., et al.: Endocrinology. en.2016-1776 (2017)

Formula: C₁₀H₁₂ClNO₂

Color and Shape: Neat

Molecular weight: 213.66

Ref: TR-B107990

(R)-4-Amino-3-(4-chlorophenyl)butanoic acid

CAS: 69308-37-8

Formula: C₁₀H₁₂ClNO₂

Purity: 98%

Color and Shape: No data available.

Molecular weight: 213.66

Ref: 10-F235816

(R)-Baclofen-d4

Controlled Product

CAS: 69308-37-8

Formula: C₁₀D₄H₈ClNO₂

Color and Shape: Neat

Molecular weight: 217.685

Ref: TR-B107992

(R)-Baclofen

CAS: 69308-37-8

Formula: C₁₀H₁₂ClNO₂

Molecular weight: 213.7

Ref: ST-EA-CP-B3024