CAS 69408-81-7
:Amonafide
Description:
Amonafide, with the CAS number 69408-81-7, is a synthetic compound that belongs to the class of anthraquinone derivatives. It is primarily recognized for its potential use as an antineoplastic agent, particularly in the treatment of certain types of cancer. Amonafide exhibits a mechanism of action that involves intercalation into DNA, leading to the disruption of DNA replication and transcription, which ultimately induces apoptosis in cancer cells. The compound is characterized by its ability to form reactive intermediates, contributing to its cytotoxic effects. Amonafide has been studied for its efficacy against various malignancies, including leukemia and solid tumors. However, its clinical use has been limited due to side effects and the development of resistance. In terms of physical properties, Amonafide is typically presented as a solid, and its solubility and stability can vary depending on the formulation and conditions. Ongoing research continues to explore its potential applications and to improve its therapeutic profile.
Formula:C16H17N3O2
InChI:InChI=1S/C16H17N3O2/c1-18(2)6-7-19-15(20)12-5-3-4-10-8-11(17)9-13(14(10)12)16(19)21/h3-5,8-9H,6-7,17H2,1-2H3
InChI key:InChIKey=UPALIKSFLSVKIS-UHFFFAOYSA-N
SMILES:O=C1C=2C=3C(C(=O)N1CCN(C)C)=CC=CC3C=C(N)C2
Synonyms:- 1H-Benz[de]isoquinoline-1,3(2H)-dione, 5-amino-2-[2-(dimethylamino)ethyl]-
- 5-Amino-2-[2-(dimethylamino)ethyl]-1H-benz[de]isoquinoline-1,3(2H)-dione
- 5-amino-2-[2-(dimethylamino)ethyl]-1H-benzo[de]isoquinoline-1,3(2H)-dione
- Benzisoquinolinedione
- Fa 142
- M-Fa 142
- Made-Fa 142
- NSC 308847
- Nafidimide
- Nci 308847
Sort by
Purity (%)
0
100
|
0
|
50
|
90
|
95
|
100
Found 5 products.
Amonafide
CAS:<p>Amonafide (NSC-308847, AS1413) causes DNA breaks via topoisomerase II, not topoisomerase I.</p>Formula:C16H17N3O2Purity:99.39%Color and Shape:SolidMolecular weight:283.33
