CAS 69409-02-5

N-{2-[2-(dimethylamino)ethyl]-1,3-dioxo-2,3-dihydro-1H-benzo[de]isoquinolin-5-yl}acetamide

Description:

N-{2-[2-(dimethylamino)ethyl]-1,3-dioxo-2,3-dihydro-1H-benzo[de]isoquinolin-5-yl}acetamide, with the CAS number 69409-02-5, is a synthetic organic compound characterized by its complex molecular structure, which includes a benzoisoquinoline core. This compound features a dimethylamino group, contributing to its potential biological activity, and an acetamide functional group, which may influence its solubility and reactivity. The presence of the 1,3-dioxo moiety suggests that it may participate in various chemical reactions, including those typical of diketones. Its structural features indicate potential applications in medicinal chemistry, particularly in the development of pharmaceuticals, due to the presence of functional groups that can interact with biological targets. Additionally, the compound's unique arrangement of atoms may confer specific properties such as lipophilicity or hydrophilicity, affecting its pharmacokinetics and bioavailability. Overall, this compound represents a class of molecules that could be of interest in drug discovery and development.

Formula: C₁₈H₁₉N₃O₃

InChI: InChI=1/C18H19N3O3/c1-11(22)19-13-9-12-5-4-6-14-16(12)15(10-13)18(24)21(17(14)23)8-7-20(2)3/h4-6,9-10H,7-8H2,1-3H3,(H,19,22)

SMILES: CC(=Nc1cc2cccc3c2c(c1)c(=O)n(CCN(C)C)c3=O)O

Synonyms:

• acetamide, N-[2-[2-(dimethylamino)ethyl]-2,3-dihydro-1,3-dioxo-1H-benz[de]isoquinolin-5-yl]-

N-Acetyl Amonafide

Controlled Product

CAS: 69409-02-5

Applications A metabolite of Amonafide.
References Felder, T.B., et al.: Drug Metab. Dispos., 15, 773 (1987), Frei, E., et al.: Cancer Res., 48, 6417 (1988), Liu, Y., et al.: Bioorg. Med. Chem., 14, 2935 (2006),

Formula: C₁₈H₁₉N₃O₃

Color and Shape: Neat

Molecular weight: 325.36

Ref: TR-A168300

N-Acetyl Amonafide

CAS: 69409-02-5

Formula: C₁₈H₁₉N₃O₃

Molecular weight: 325.36

Ref: ST-EA-CP-A397002

N-Acetyl amonafide

CAS: 69409-02-5

N-Acetyl amonafide (NAA) is a potent antitumor agent that has shown activity against urothelial carcinoma, prostate cancer cells and skin cancer. It is an inhibitor of the uptake and efflux of anticancer drugs in tumor cells. NAA inhibits the growth of prostate cancer cells by inhibiting protein synthesis through inhibition of protein tyrosine phosphatase (PTP) activity. This drug has been shown to be effective in inhibiting the growth of human fetal bovine kidney cells and inducing apoptosis in these cells. NAA also inhibits the proliferation of human bladder cancer cells in culture by inhibiting DNA synthesis and causing cell cycle arrest. The molecular docking analysis revealed that NAA binds to topoisomerase II alpha, which is an enzyme involved in DNA replication, repair and transcription.

Formula: C₁₈H₁₉N₃O₃

Purity: Min. 95%

Molecular weight: 325.36 g/mol

Ref: 3D-FA17012