CAS 696-04-8

Dihydrothymine

Description:

Dihydrothymine, with the CAS number 696-04-8, is a pyrimidine derivative and a reduced form of thymine, one of the four nucleobases in DNA. It is characterized by the presence of two additional hydrogen atoms, which results in a saturated structure compared to the unsaturated nature of thymine. Dihydrothymine is typically a white to off-white crystalline solid, and it is soluble in polar solvents such as water and alcohols. The compound is of interest in biochemical research, particularly in studies related to DNA repair and the effects of oxidative stress on nucleobases. Its reduced structure can influence the stability and reactivity of nucleic acids, making it a relevant subject in the fields of molecular biology and medicinal chemistry. Additionally, dihydrothymine can serve as a model compound for understanding the mechanisms of DNA damage and repair processes, as well as the development of therapeutic agents targeting nucleic acid interactions.

Formula: C₅H₈N₂O₂

InChI: InChI=1S/C5H8N2O2/c1-3-2-6-5(9)7-4(3)8/h3H,2H2,1H3,(H2,6,7,8,9)

InChI key: InChIKey=NBAKTGXDIBVZOO-UHFFFAOYSA-N

SMILES: O=C1C(C)CNC(=O)N1

Synonyms:

• (5R)-5-methyldihydropyrimidine-2,4(1H,3H)-dione
• (5S)-5-methyldihydropyrimidine-2,4(1H,3H)-dione
• 2,4(1H,3H)-Pyrimidinedione, dihydro-5-methyl-
• 2-Hydroxy-5-methyl-5,6-dihydro-1H-pyrimidin-4-one
• 5,6-Dihydro-5-methyluracil
• 5,6-Dihydrothymine
• 5-Methyl-5,6-dihydrouracil
• 5-methyldihydropyrimidine-2,4(1H,3H)-dione
• Dihydro-5-methyl-2,4(1H,3H)-pyrimidinedione
• Dihydrothymine
• Hydrouracil, 5-methyl-

5,6-Dihydro-5-methyluracil, 98+%

CAS: 696-04-8

5,6-Dihydro-5-methyluracil, is used as an active pharmaceutical ingredient. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or S

Formula: C₅H₈N₂O₂

Purity: 98+%

Color and Shape: Crystals or crystalline powder, White to pale cream

Molecular weight: 128.13

Ref: 02-L01996

5,6-Dihydro-5-methyluracil

CAS: 696-04-8

Formula: C₅H₈N₂O₂

Purity: 97%

Color and Shape: Solid

Molecular weight: 128.1292

Ref: IN-DA003MA0

5,6-Dihydro-5-methyluracil

CAS: 696-04-8

5,6-Dihydro-5-methyluracil (Dihydrothymine) is an intermediate breakdown product of thymine.

Formula: C₅H₈N₂O₂

Purity: 98.53%

Color and Shape: Solid

Molecular weight: 128.13

Ref: TM-T0532

5,6-Dihydro-5-methyluracil

CAS: 696-04-8

5,6-Dihydro-5-methyluracil

Purity: ≥98%

Molecular weight: 128.13g/mol

Ref: 54-BUP14147

5,6-Dihydro-5-methyluracil

CAS: 696-04-8

5,6-Dihydro-5-methyluracil

Purity: 97%

Molecular weight: 128.13g/mol

Ref: 54-OR1026137

5,6-Dihydrothymine-α,alphaalpha,5,6,6-d6 -6

CAS: 334473-42-6, 696-04-8

Purity: 99 atom % D

Molecular weight: 134.17

Ref: 3U-D7687

5,6-Dihydro Thymine

Controlled Product

CAS: 696-04-8

Applications 5,6-Dihydrothymine is a derivative of Thymine, a nucleobase in the nucleic acid of DNA . 5,6-Dihydrothymine is a radiolysis product of DNA.
References Hubbard, K. et al.: Biochemistry, 28, 4382 (1989); Cadet, J. et al.: Int. J. Rad. Biol. Rel. Stud. Phys. Chem. Med., 39, 119 (1981);

Formula: C₅H₈N₂O₂

Color and Shape: Neat

Molecular weight: 128.13

Ref: TR-D449440

5-Methyl-dihydro-pyrimidine-2,4-dione

CAS: 696-04-8

Formula: C₅H₈N₂O₂

Purity: 97%

Color and Shape: Solid

Molecular weight: 128.131

Ref: 10-F487619

5,6-Dihydro Thymine

CAS: 696-04-8

5,6-Dihydrothymine is a metabolic precursor to thymine. It has been shown to inhibit the production of DNA and RNA in cells, which causes cellular transformation. 5,6-Dihydrothymine also inhibits enzyme activity by competing with substrates or by forming covalent bonds with the enzyme. This drug has been found to be genotoxic and may cause cancer, but it can also be used for diagnosis and treatment of radiation-induced genetic damage. The drug is an oral prodrug that is hydrolyzed in the gastrointestinal tract to release thymine. 5,6-Dihydrothymine is used for molecular pathogenesis studies on solid tumours, such as breast cancer and prostate cancer.

Formula: C₅H₈N₂O₂

Purity: Min. 95%

Molecular weight: 128.13 g/mol

Ref: 3D-AAA69604