CAS 696-06-0

5,6-Dihydro-5-fluorouracil

Description:

5,6-Dihydro-5-fluorouracil is a fluorinated derivative of uracil, classified as a pyrimidine analog. It is primarily recognized for its role in cancer treatment, particularly in the context of chemotherapy, due to its ability to inhibit thymidylate synthase, an enzyme critical for DNA synthesis. This compound is characterized by the presence of a fluorine atom at the 5-position of the uracil ring, which enhances its antitumor activity. In terms of physical properties, 5,6-dihydro-5-fluorouracil is typically a white to off-white crystalline solid, soluble in water and various organic solvents. Its chemical structure allows it to mimic natural nucleotides, leading to its incorporation into RNA and DNA, which disrupts normal cellular processes. The compound is often studied for its potential in combination therapies and its effects on various cancer cell lines. Safety and handling precautions are essential, as with many chemotherapeutic agents, due to its potential toxicity and side effects.

Formula: C₄H₅FN₂O₂

InChI: InChI=1S/C4H5FN2O2/c5-2-1-6-4(9)7-3(2)8/h2H,1H2,(H2,6,7,8,9)

InChI key: InChIKey=RAIRJKWTBBDDAR-UHFFFAOYSA-N

SMILES: O=C1C(F)CNC(=O)N1

Synonyms:

• 2,4(1H,3H)-pyrimidinedione, 5-fluorodihydro-
• 5,6-Dihydro-5-fluorouracil
• 5-Fluoro-5,6-dihydrouracil
• 5-Fluorodihydro-2,4(1H,3H)-pyrimidinedione
• 5-Fluorodihydrouracil
• 5-Fluorohydrouracil
• Dihydro-5-fluorouracil
• Hydrouracil, 5-fluoro-
• 5-Fluorodihydropyrimidine-2,4(1H,3H)-dione

5,6-dihydro-5-Fluorouracil

CAS: 696-06-0

5,6-dihydro-5-Fluorouracil (5-FUH2) is an inactive metabolite of 5-FU and can be used for the study of organismal metabolism.

Formula: C₄H₅FN₂O₂

Color and Shape: Solid

Molecular weight: 132.09

Ref: TM-T36870

5,6-Dihydro-5-Fluorouracil

CAS: 696-06-0

5,6-Dihydro-5-Fluorouracil

Purity: 98%

Ref: 54-PC1001137

5,6-Dihydro-5-Fluorouracil

CAS: 696-06-0

Formula: C₄H₅FN₂O₂

Molecular weight: 132.09

Ref: 4Z-F-5318

5-Fluorodihydropyrimidine-2,4-dione

Controlled Product

CAS: 696-06-0

Applications A metabolite of 5-Fluorouracil. (F596000)
References Bocci, G., et al.: Eur. J. Clin. Pharmacol., 58, 593 (2002), Longley, D.B., Nature Rev. Cancer, 3, 330 (2003), Fischel, J., et al.: Anti-Cancer Drugs, 15, 969 (2004)

Formula: C₄H₅FN₂O₂

Color and Shape: Neat

Molecular weight: 132.093

Ref: TR-F591025

5-Fluorodihydropyrimidine-2,4-dione

CAS: 696-06-0

5-Fluorodihydropyrimidine-2,4-dione is a drug that inhibits the activity of certain enzymes. It has been shown to inhibit the activity of dehydrogenase in human serum and liver cells. This drug has also been shown to be successful in treating autoimmune diseases. 5-Fluorodihydropyrimidine-2,4-dione is an oral prodrug which is converted into its active form by esterases in the gastrointestinal tract. The enzyme inhibitors are used to increase the bioavailability of the drug. This conversion process can be monitored using urine samples or blood sampling.

Formula: C₄H₅FN₂O₂

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 132.09 g/mol

Ref: 3D-FF23436

5-FLUORO-DIHYDRO-PYRIMIDINE-2,4-DIONE

CAS: 696-06-0

Formula: C₄H₅FN₂O₂

Purity: 97.0%

Color and Shape: Solid

Molecular weight: 132.094

Ref: 10-F514001

5-Fluorodihydropyrimidine-2,4-Dione

CAS: 696-06-0

Formula: C₄H₅FN₂O₂

Molecular weight: 132.09

Ref: ST-EA-CP-F32012