CAS 696-07-1

5-Iodouracil

Description:

5-Iodouracil is a halogenated derivative of uracil, classified as a pyrimidine nucleobase. Its chemical structure features an iodine atom substituted at the 5-position of the uracil ring, which influences its biological activity and properties. This compound is known for its role as an antimetabolite, particularly in the context of cancer treatment, as it can interfere with nucleic acid synthesis. 5-Iodouracil exhibits moderate solubility in water and is typically stable under standard laboratory conditions. Its molecular formula is C4H3I N2O2, and it has a relatively low molecular weight. The presence of the iodine atom enhances its reactivity and can affect its interaction with enzymes and nucleic acids. In research, 5-Iodouracil is often utilized in studies related to nucleic acid metabolism and the development of antiviral and anticancer agents. Safety precautions should be taken when handling this compound, as with many halogenated organic substances, due to potential toxicity and environmental impact.

Formula: C₄H₃IN₂O₂

InChI: InChI=1S/C4H3IN2O2/c5-2-1-6-4(9)7-3(2)8/h1H,(H2,6,7,8,9)

InChI key: InChIKey=KSNXJLQDQOIRIP-UHFFFAOYSA-N

SMILES: O=C1C(I)=CNC(=O)N1

Synonyms:

• 2,4(1H,3H)-Pyrimidinedione, 5-iodo-
• 2,4-Dihydroxy-5-Iodopyrimidine
• 3H)-Pyrimidinedione,5-Iodo-4(1H
• 5-I-U
• 5-Iodo-2,4(1H,3H)-pyrimidinedione
• 5-Iodo-2,4-dihydroxypyrimidine
• 5-Iodo-2,4-pyrimidinedione
• 5-Iodo-Uraci
• 5-Iodopyrimidine-2,4-diol
• 5-iodopyrimidine-2,4(1H,3H)-dione
• 5IU
• NSC 57848
• Uracil, 5-iodo-
• 5-Iodouracil

5-Iodouracil

CAS: 696-07-1

Formula: C₄H₃IN₂O₂

Purity: >99.0%(T)(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 237.98

Ref: 3B-I0219

5-Iodouracil, 97%

CAS: 696-07-1

It is used as an intermediate. It has an antitumor activity. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference ha

Formula: C₄H₃IN₂O₂

Purity: 97%

Color and Shape: Powder, White to pale cream

Molecular weight: 237.98

Ref: 02-A18994

5-Iodouracil

CAS: 696-07-1

Formula: C₄H₃IN₂O₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 237.9833

Ref: IN-DA003MTD

5-Iodouracil

CAS: 696-07-1

Formula: C₄H₃IN₂O₂

Molecular weight: 237.99

Ref: 7W-GN4819

5-Iodouracil

CAS: 696-07-1

5-Iodouracil is a Heterocyclic compound-pyrimidine, intermediate and building block, halo-.

Formula: C₄H₃IN₂O₂

Color and Shape: Solid

Molecular weight: 237.98

Ref: TM-TNU0628

5-Iodouracil

CAS: 696-07-1

5-Iodouracil

Formula: C₄H₃IN₂O₂

Purity: 97%

Color and Shape: off white solid

Molecular weight: 237.98g/mol

Ref: 54-OR18306

5-Iodouracil

Controlled Product

CAS: 696-07-1

Applications 5-Iodouracil is a halogenated pyrimidine that can be used in nucleoprotein photo-crosslinking via RNA substitution. 5-Iodouracil is used in thymidine phosphorylase targeted imaging and therapy. Studies show that DNA N-glycosylase MED1 exhibited higher preference for 5-Iodouracil and halogenated bases over non-halogenated ones.
References Meisenheimer, K. et al.: Meth. Enzymol., 318, 88 (2000); Klecker, R.W. Jr. et al.: Cancer Chemother. Pharmacol., 48, 407 (2001); Turner, D.P. et al.: Cancer Res., 66, 7686 (2006);

Formula: C₄H₃IN₂O₂

Color and Shape: Neat

Molecular weight: 237.98

Ref: TR-I728900

5-Iodouracil extrapure, 98%

CAS: 696-07-1

Formula: C₄H₃IN₂O₂

Purity: min. 98%

Color and Shape: White to off-white, Crystalline powder

Molecular weight: 238.00

Ref: SR-99918

5-Iodouracil

CAS: 696-07-1

Formula: C₄H₃IN₂O₂

Purity: 96%

Color and Shape: Solid, White powder

Molecular weight: 237.984

Ref: 10-F036416

5-Iodouracil

CAS: 696-07-1

5-Iodouracil is an irreversible inhibitor of 5-hydroxytryptamine 2B receptor (5-HT2B) that is a group p2 molecule. It has been found to be effective in the treatment of various types of cancer, including colorectal cancer. 5-Iodouracil inhibits cell proliferation by blocking the binding of the growth factor to its receptor on the surface of cells. The drug also inhibits the enzyme activities of human serum albumin and tyrosine phosphatase.

Formula: C₄H₃IN₂O₂

Purity: Min. 97 Area-%

Color and Shape: White Powder

Molecular weight: 237.98 g/mol

Ref: 3D-FI11503