CAS 69610-40-8

N-ALPHA-tert-Butoxycarbonyl-L-prolinol

Description:

N-Alpha-tert-Butoxycarbonyl-L-prolinol, with the CAS number 69610-40-8, is an organic compound commonly used in peptide synthesis and as a protecting group in organic chemistry. This compound features a prolinol backbone, which is an amino alcohol derived from proline, and is modified with a tert-butoxycarbonyl (Boc) group. The Boc group serves as a protective moiety for the amino function, allowing for selective reactions without interfering with the amine's reactivity. N-Alpha-tert-Butoxycarbonyl-L-prolinol is typically a white to off-white solid and is soluble in common organic solvents such as dichloromethane and methanol. Its stability under various conditions makes it a valuable intermediate in the synthesis of pharmaceuticals and biologically active compounds. Additionally, the presence of the prolinol structure imparts unique stereochemical properties, which can influence the conformation and biological activity of the resulting peptides. Proper handling and storage are essential, as with many organic compounds, to maintain its integrity and effectiveness in synthetic applications.

Formula: C₁₀H₁₉NO₃

InChI: InChI=1/C10H19NO3/c1-10(2,3)14-9(13)11-6-4-5-8(11)7-12/h8,12H,4-7H2,1-3H3/t8-/m1/s1

SMILES: CC(C)(C)OC(=O)N1CCC[C@@H]1CO

Synonyms:

• BOC-L-Prolinol
• N-Boc-L-prolinol
• Boc-Pro-ol
• N-(tert-Butoxycarbonyl)-L-prolinol
• (S)-(-)-1-tert-Butoxycarbonyl-2-pyrrolidinemethanol
• Tert-Butyl 2-(Hydroxymethyl)Pyrrolidine-1-Carboxylate
• tert-butyl (2S)-2-(hydroxymethyl)pyrrolidine-1-carboxylate
• tert-butyl (2R)-2-(hydroxymethyl)pyrrolidine-1-carboxylate
• (S)-(-)-1-Boc-2-Pyrrolidinemethanol
• 1-Pyrrolidinecarboxylic acid, 2-(hydroxymethyl)-, 1,1-dimethylethyl ester, (2S)-
• 2-Hydroxymethylpyrrolidine-1-carboxylic acid tert butyl ester

N-(tert-Butoxycarbonyl)-L-prolinol

CAS: 69610-40-8

Formula: C₁₀H₁₉NO₃

Purity: >98.0%(GC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 201.27

Ref: 3B-B3077

N-Boc-L-prolinol, 98+%

CAS: 69610-40-8

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Sci

Formula: C₁₀H₁₉NO₃

Purity: 98+%

Color and Shape: crystalline powder, White

Molecular weight: 201.27

Ref: 02-L09885

tert-Butyl (S)-2-(hydroxymethyl)pyrrolidine-1-carboxylate

CAS: 69610-40-8

Formula: C₁₀H₁₉NO₃

Purity: 97%

Color and Shape: Solid

Molecular weight: 201.2628

Ref: IN-DA0035D1

N-Boc-L-prolinol

CAS: 69610-40-8

Formula: C₁₀H₁₉NO₃

Molecular weight: 201.27

Ref: 7W-GM9411

(2S)-(+)-2-(Hydroxymethyl)pyrrolidine, N-BOC protected

CAS: 69610-40-8

(2S)-(+)-2-(Hydroxymethyl)pyrrolidine, N-BOC protected

Formula: C₁₀H₁₉NO₃

Purity: ≥95%

Color and Shape: slightly yellow powder

Molecular weight: 201.26g/mol

Ref: 54-OR14516

N-Boc-L-prolinol

CAS: 69610-40-8

N-Boc-L-prolinol is a chiral proline derivative that has been modified with an allyl group. It is a potent nicotinic acetylcholine antagonist, and it has been shown to have immune functions in vitro. The synthesis of N-Boc-L-prolinol occurs through a three-step process involving the use of organocatalysts, asymmetric synthesis, and stereoselective reactions. This molecule is also useful for the study of apoptotic signaling pathways in cells.

Formula: C₁₀H₁₉NO₃

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 201.26 g/mol

Ref: 3D-FB28954

1-Boc-L-Prolinol

CAS: 69610-40-8

Formula: C₁₀H₁₉NO₃

Purity: 97%

Color and Shape: Solid

Molecular weight: 201.266

Ref: 10-F048696

tert-Butyl (S)-2-(hydroxymethyl)pyrrolidine-1-carboxylate

Controlled Product

CAS: 69610-40-8

Applications tert-Butyl (S)-2-(hydroxymethyl)pyrrolidine-1-carboxylate, is a building block used foe the synthesis of novel nicotinic acetylcholine receptor ligands with cognition-enhancing properties. It can also be used in the synthesis of chiral β-amino sulfides and β-amino thiols.
References Elliiot, R. L., et al.: Bioorg. Med. Chem. Lett., 6, 2283 (1996); Abreo, M. A., et al.: J. Med. Chem., 39(4), 817 (1996);

Formula: C₁₀H₁₉NO₃

Color and Shape: Neat

Molecular weight: 201.26

Ref: TR-B692205