CAS 697299-82-4

Lapatinib Impurity 3

CAS: 697299-82-4

Formula: C₂₆H₂₀ClFN₄O₂

Color and Shape: Pale Yellow Solid

Molecular weight: 474.92

Ref: 4Z-L-258

N-De[2-(methylsulfonyl)ethyl] Lapatinib

Controlled Product

CAS: 697299-82-4

Applications A reactive metabolite of Lapatinib (L175800) which is associated with various drug toxicities. Lapatinib is metabolized mainly by P450 3A4 to form O- and N-dealkylated metabolites.
References He, K., et al.: Chem. Res. Toxicol., 11, 252 (1998), Rusnuk, D., et al.: Cancer Res., 61, 7196 (2001), Li, X., et al.: Drug Metab. Dispos., 37, 1242 (2009),

Formula: C₂₆H₂₀ClFN₄O₂

Color and Shape: Neat

Molecular weight: 474.91

Ref: TR-D231270

N-De[2-(methylsulfonyl)ethyl] lapatinib

CAS: 697299-82-4

Lapatinib is a tyrosine kinase inhibitor that blocks the epidermal growth factor receptor (EGFR) and other tyrosine kinases. It is used in cancer treatment to inhibit tumor growth, with a high success rate. Lapatinib is also used to treat lung cancer and other types of cancer. The drug has been shown to inhibit EGFR phosphorylation in vitro, which leads to inhibition of cell proliferation and induction of apoptosis. Lapatinib also inhibits the expression of EGFR downstream target genes such as b-raf, serine/threonine-protein kinase, and cyp3a5.

Formula: C₂₆H₂₀ClFN₄O₂

Purity: Min. 95%

Molecular weight: 474.91 g/mol

Ref: 3D-ID20812