CAS 69739-16-8

Cefodizime

Description:

Cefodizime is a broad-spectrum cephalosporin antibiotic, classified under the third generation of cephalosporins. It is primarily used for the treatment of various bacterial infections due to its effectiveness against both Gram-positive and Gram-negative bacteria. Cefodizime works by inhibiting bacterial cell wall synthesis, leading to cell lysis and death. The compound is characterized by its stability against certain beta-lactamases, which enhances its efficacy against resistant strains. It is typically administered via injection and has a favorable pharmacokinetic profile, allowing for effective tissue penetration. Common indications for cefodizime include respiratory tract infections, urinary tract infections, and skin infections. As with other antibiotics, it is essential to use cefodizime judiciously to minimize the risk of developing antibiotic resistance. Potential side effects may include allergic reactions, gastrointestinal disturbances, and alterations in blood parameters. Overall, cefodizime represents a valuable option in the arsenal of antimicrobial therapies, particularly in settings where resistance to other antibiotics is a concern.

Formula: C₂₀H₂₀N₆O₇S₄

InChI: InChI=1/C20H20N6O7S4/c1-7-10(3-11(27)28)37-20(22-7)36-5-8-4-34-17-13(16(30)26(17)14(8)18(31)32)24-15(29)12(25-33-2)9-6-35-19(21)23-9/h6,13,17H,3-5H2,1-2H3,(H2,21,23)(H,24,29)(H,27,28)(H,31,32)/b25-12+/t13-,17-/m1/s1

InChI key: InChIKey=XDZKBRJLTGRPSS-BGZQYGJUSA-N

SMILES: C(O)(=O)C=1N2[C@@]([C@H](NC(/C(=N\OC)/C=3N=C(N)SC3)=O)C2=O)(SCC1CSC=4SC(CC(O)=O)=C(C)N4)[H]

Synonyms:

• (6R,7R)-7-[[(2Z)-2-(2-Amino-4-thiazolyl)-2-(methoxyimino)acetyl]amino]-3-[[[5-(carboxymethyl)-4-methyl-2-thiazolyl]thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
• (6R,7R)-7-{[(2E)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-3-({[5-(carboxymethyl)-4-methyl-1,3-thiazol-2-yl]sulfanyl}methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
• (6R,7R)-7-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-3-({[5-(carboxymethyl)-4-methyl-1,3-thiazol-2-yl]sulfanyl}methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
• 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]-3-[[[5-(carboxymethyl)-4-methyl-2-thiazolyl]thio]methyl]-8-oxo-, [6R-[6α,7β(Z)]]-
• 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2Z)-(2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]-3-[[[5-(carboxymethyl)-4-methyl-2-thiazolyl]thio]methyl]-8-oxo-, (6R,7R)-
• 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2Z)-2-(2-amino-4-thiazolyl)-2-(methoxyimino)acetyl]amino]-3-[[[5-(carboxymethyl)-4-methyl-2-thiazolyl]thio]methyl]-8-oxo-, (6R,7R)-
• 7-(((2-Amino-4-Thiazolyl)(Methoxyimino)Acetyl)Amino)-3-(((5-(Carboxymethyl)-4-Methyl-2-Thiazolyl)Thio)Methyl)-8-Oxo-5-Thia-1-Azabicyclo(4.2.0)Oct-2-Ene-2-Carboxylic Acid
• 7-(α-(Z)-Methoxyimino-α-(2-aminothiazol-4-yl)acetamido)-3-((5-carboxymethyl-4-methylthiazol-2-yl)thiomethyl)-3-cephem-4-carboxylic acid
• Cefodizime acid
• Cefodizime
• FIR-221

5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid,7-[[(2Z)-(2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]-3-[[[5-(carboxymethyl)-4-methyl-2-thiazolyl]thio]methyl]-8-oxo-, (6R,7R)-

CAS: 69739-16-8

Formula: C₂₀H₂₀N₆O₇S₄

Purity: 97%

Color and Shape: Solid

Molecular weight: 584.6688

Ref: IN-DA01CCIC

Cefodizime

CAS: 69739-16-8

Cefodizime

Purity: ≥98%

Molecular weight: 584.67g/mol

Ref: 54-BUP13742

Cefodizime

CAS: 69739-16-8

Formula: C₂₀H₂₀N₆O₇S₄

Molecular weight: 584.66

Ref: 4Z-C-313001

Cefodizime

CAS: 69739-16-8

Cefodizime: a new, well-tolerated cephalosporin antibiotic with immunomodulatory properties for serious respiratory and urinary infections.

Formula: C₂₀H₂₀N₆O₇S₄

Purity: 99.62%

Color and Shape: Solid

Molecular weight: 584.67

Ref: TM-T14922

Cefodizime

CAS: 69739-16-8

Applications Cefodizime is a third generation cephalosporin with a broad spectrum of antibacterial activity. Cefodizime maybe useful in the treatment of otitis media, sinusitis and gynaecological infections, and for the prophylaxis or treatment of surgical infections.
References Barradel, L.B. et al.: Drugs, 44, 800 (1992); Kasai, K. et al.: Jap. J. Antibiot., 37, 1306 (1984);

Formula: C₂₀H₂₀N₆O₇S₄

Color and Shape: Neat

Molecular weight: 584.67

Ref: TR-C242865

Cefodizime

CAS: 69739-16-8

Cefodizime is a third-generation cephalosporin antibiotic, which is derived from the fungus Acremonium. It exerts its bactericidal effects by inhibiting bacterial cell wall synthesis. This action is achieved through binding to penicillin-binding proteins (PBPs), leading to the interruption of peptidoglycan cross-linking essential for the bacterial cell wall integrity. The breakdown of cell wall synthesis results in the lysis and death of the bacterial cell.

Purity: Min. 95%

Ref: 3D-FC35157