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CAS 69756-53-2

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Halofantrine

Description:
Halofantrine is an antimalarial drug primarily used for the treatment of malaria, particularly in cases caused by Plasmodium falciparum. It is classified as a phenanthrene methanol derivative and exhibits a complex chemical structure that contributes to its pharmacological activity. Halofantrine is known for its ability to interfere with the heme detoxification process in the malaria parasite, leading to its death. The substance is typically administered orally and is characterized by its low solubility in water, which can affect its bioavailability. It is important to note that halofantrine has a potential for cardiotoxicity, particularly at higher doses, necessitating careful monitoring of heart function during treatment. The drug is metabolized in the liver, and its pharmacokinetics can be influenced by various factors, including food intake and co-administration with other medications. Due to its side effects and the emergence of drug-resistant malaria strains, halofantrine is often used in combination with other antimalarial agents to enhance efficacy and reduce the risk of resistance development.
Formula:C26H30Cl2F3NO
InChI:InChI=1S/C26H30Cl2F3NO/c1-3-5-10-32(11-6-4-2)12-9-25(33)23-16-22-21(14-18(27)15-24(22)28)20-13-17(26(29,30)31)7-8-19(20)23/h7-8,13-16,25,33H,3-6,9-12H2,1-2H3
InChI key:InChIKey=FOHHNHSLJDZUGQ-UHFFFAOYSA-N
SMILES:C(CCN(CCCC)CCCC)(O)C1=C2C(=C3C(=C1)C(Cl)=CC(Cl)=C3)C=C(C(F)(F)F)C=C2
Synonyms:
  • (.+-.)-Halofantrine
  • 1,3-Dichloro-α-[2-(dibutylamino)ethyl]-6-(trifluoromethyl)-9-phenanthrenemethanol
  • Halfan
  • Halofantrin
  • Halofantrina
  • dl-WR 171669
  • 9-Phenanthrenemethanol, 1,3-dichloro-α-[2-(dibutylamino)ethyl]-6-(trifluoromethyl)-
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