CAS 69819-86-9

Darinaparsin

Description:

Darinaparsin, with the CAS number 69819-86-9, is an organoarsenic compound that has garnered attention in the field of medicinal chemistry, particularly for its potential use in cancer therapy. It is characterized by its unique structure, which includes an arsenic atom bonded to organic moieties, contributing to its biological activity. Darinaparsin exhibits properties that allow it to interact with cellular pathways, potentially inducing apoptosis in cancer cells. Its mechanism of action is thought to involve the generation of reactive oxygen species and the disruption of cellular redox balance. The compound has been studied for its efficacy against various types of tumors, and its safety profile is under investigation in clinical settings. As with many organometallic compounds, the handling and usage of Darinaparsin require caution due to the toxicity associated with arsenic. Ongoing research aims to better understand its pharmacokinetics, optimal dosing regimens, and the full scope of its therapeutic potential.

Formula: C₁₂H₂₂AsN₃O₆S

InChI: InChI=1S/C12H22AsN3O6S/c1-13(2)23-6-8(11(20)15-5-10(18)19)16-9(17)4-3-7(14)12(21)22/h7-8H,3-6,14H2,1-2H3,(H,15,20)(H,16,17)(H,18,19)(H,21,22)/t7-,8-/m0/s1

InChI key: InChIKey=JGDXFQORBMPJGR-YUMQZZPRSA-N

SMILES: [C@@H](NC(CC[C@@H](C(O)=O)N)=O)(C(NCC(O)=O)=O)CS[As](C)C

Synonyms:

• <span class="text-smallcaps">L</smallcap>-γ-Glutamyl-S-(dimethylarsino)-<smallcap>L</span>-cysteinylglycine
• DMS(III)G，SGLU1，ZIO-101，Zinapar
• Darinaparsin
• Dimethylarsinic glutathione
• Glycine, <span class="text-smallcaps">L</smallcap>-γ-glutamyl-S-(dimethylarsino)-<smallcap>L</span>-cysteinyl-
• Glycine, N-[S-(dimethylarsino)-N-<span class="text-smallcaps">L</smallcap>-γ-glutamyl-<smallcap>L</span>-cysteinyl]-
• Zinapar
• Zio 101
• Glycine, N-[S-(dimethylarsino)-N-L-γ-glutamyl-L-cysteinyl]-
• Glycine, L-γ-glutamyl-S-(dimethylarsino)-L-cysteinyl-
• L-γ-Glutamyl-S-(dimethylarsino)-L-cysteinylglycine

Darinaparsin-d5

Controlled Product

CAS: 69819-86-9

Formula: C₁₂H₁₇D₅AsN₃O₆S

Color and Shape: Neat

Molecular weight: 416.34

Ref: TR-D193427

Darinaparsin

Controlled Product

CAS: 69819-86-9

Applications Darinaparsin is an arsenic cytotoxin that has been used in pharmacological activities to evaluate the effect on survival an radiosensitivity of tumor cells in vitro under normoxia and hypoxia and in vivo using xenograft models. Darinaparsin has significant and preferential cytotoxic and radiosensitizing effects on solid tumors as compared with normal cells.  Darinaparsin may therefore increase the therapeutic index of radiation therapy and has near term translational potential.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Tian, J., et al.: Clin. Cancer Res., 18, 3366 (2012); Ning, S., et al.: Int. J. Radiat. Oncol. Biol. Phys., 65, 493 (2006);

Formula: C₁₂H₂₂AsN₃O₆S

Color and Shape: Neat

Molecular weight: 411.31

Ref: TR-D193425

Darinaparsin-d3

Controlled Product

CAS: 69819-86-9

Formula: C₁₂H₁₉D₃AsN₃O₆S

Color and Shape: Neat

Molecular weight: 414.32

Ref: TR-D193428

Darinaparsin

CAS: 69819-86-9

Darinaparsin, a dimethylated arsenic-glutathione compound, is cytotoxic to various cancer cells with diverse IC50 values and inhibits tumor growth in mice.

Formula: C₁₂H₂₂AsN₃O₆S

Color and Shape: Solid

Molecular weight: 411.31

Ref: TM-T35940