CAS 69975-86-6

Doxofylline

Description:

Doxofylline is a xanthine derivative primarily used as a bronchodilator in the treatment of respiratory conditions such as asthma and chronic obstructive pulmonary disease (COPD). It exhibits a dual mechanism of action, functioning as both a bronchodilator and an anti-inflammatory agent. Doxofylline is characterized by its ability to relax bronchial smooth muscles, thereby improving airflow and reducing respiratory distress. Its chemical structure includes a methylxanthine core, which is responsible for its pharmacological effects. The substance is known for its favorable safety profile and lower incidence of side effects compared to other xanthine derivatives, such as theophylline. Doxofylline is typically administered orally and has a relatively long half-life, allowing for less frequent dosing. Additionally, it is often preferred in patients who may be sensitive to the side effects associated with traditional bronchodilators. Overall, doxofylline represents a valuable therapeutic option in managing obstructive airway diseases, contributing to improved patient outcomes.

Formula: C₁₁H₁₄N₄O₄

InChI: InChI=1S/C11H14N4O4/c1-13-9-8(10(16)14(2)11(13)17)15(6-12-9)5-7-18-3-4-19-7/h6-7H,3-5H2,1-2H3

InChI key: InChIKey=HWXIGFIVGWUZAO-UHFFFAOYSA-N

SMILES: C(N1C2=C(N(C)C(=O)N(C)C2=O)N=C1)C3OCCO3

Synonyms:

• 1H-purine-2,6-dione, 7-(1,3-dioxolan-2-ylmethyl)-3,7-dihydro-1,3-dimethyl-
• 2-(7′-Theophyllinemethyl)-1,3-dioxolane
• 7-(1,3-Dioxolan-2-ylmethyl)-3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione
• 7-(1,3-dioxolan-2-ylmethyl)-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione
• Abc 12/3
• Abc 1213
• Ansimar
• Dioxyfilline
• Doxophylline
• Maxivent
• Synasma
• Theophylline, 7-(1,3-dioxolan-2-ylmethyl)-

Doxofylline

CAS: 69975-86-6

Formula: C₁₁H₁₄N₄O₄

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 266.26

Ref: 3B-D4302

Doxofylline

CAS: 69975-86-6

Xanthine bronchodilator that inhibits phosphodiesterase activity

Formula: C₁₁H₁₄N₄O₄

Molecular weight: 266.25

Ref: 02-J60575

Doxofylline

CAS: 69975-86-6

Doxofylline (Doxophylline) is a methylxanthine derivative with the presence of a dioxolane group in position 7.

Formula: C₁₁H₁₄N₄O₄

Purity: 99.958% - >99.99%

Color and Shape: Solid

Molecular weight: 266.25

Ref: TM-T0480

7-(1,3-Dioxolan-2-ylmethyl)-3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione

CAS: 69975-86-6

Formula: C₁₁H₁₄N₄O₄

Purity: %

Color and Shape: Solid

Molecular weight: 266.2533

Ref: IN-DA00IBZW

Doxofylline

CAS: 69975-86-6

Formula: C₁₁H₁₄N₄O₄

Molecular weight: 266.26

Ref: 4Z-D-129001

Doxofylline

CAS: 69975-86-6

Doxofylline

Purity: 98%

Molecular weight: 266.25g/mol

Ref: 54-OR1030265

Doxofylline

CAS: 69975-86-6

Doxofylline

Purity: ≥98%

Molecular weight: 266.25g/mol

Ref: 54-BUP14686

Doxofylline

CAS: 69975-86-6

Formula: C₁₁H₁₄N₄O₄

Molecular weight: 266.25

Ref: 7W-GP2974

Doxofylline

Controlled Product

CAS: 69975-86-6

Applications Doxofylline is a xanthine molecule that appears to be both bronchodilator and anti-inflammatory with an improved therapeutic window over conventional xanthines such as Theophylline and the evidence supporting the effects of Doxofylline in the treatment of lung diseases.
References Franzone, J., et al.: Drugs Exp. Clin. Res., 14, 479 (1988), Nicholson, C., et al.: Pulm. Pharmacol., 7, 1 (1994), Sullivan, P., et al.: Lancet, 343, 1006 (1994),

Formula: C₁₁H₁₄N₄O₄

Color and Shape: Neat

Molecular weight: 266.25

Ref: TR-D557100

Doxofylline - Bio-X ™

Controlled Product

CAS: 69975-86-6

Doxofylline is a methylxanthine derivative that is used to treat chronic obstructive pulmonary disease (COPD) and asthma. This drug’s mechanism of action is unclear however it is believed to be through inhibition of phosphodiesterase activity. As a result of this, cAMP levels are increased, promoting smooth muscle relaxation.

Formula: C₁₁H₁₄N₄O₄

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 266.25 g/mol

Ref: 3D-BD164389

Doxofylline

Controlled Product

CAS: 69975-86-6

Phosphodiesterase inhibitor; bronchodilator

Formula: C₁₁H₁₄N₄O₄

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 266.25 g/mol

Ref: 3D-FD65012

Doxophylline

CAS: 69975-86-6

Formula: C₁₁H₁₄N₄O₄

Purity: 99+%

Color and Shape: Solid

Molecular weight: 266.257

Ref: 10-F462728