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CAS 70-25-7

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N-methyl-N'-nitro-N-nitrosoguanidine

Description:
N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) is a potent alkylating agent known for its role in cancer research and mutagenesis studies. It is a nitrosourea compound that contains a nitro group and a nitrosamine structure, contributing to its reactivity. MNNG is typically a yellow crystalline solid that is soluble in organic solvents but has limited solubility in water. Its primary mechanism of action involves the transfer of alkyl groups to DNA, leading to the formation of DNA adducts, which can result in mutations and ultimately contribute to carcinogenesis. Due to its mutagenic properties, MNNG is often used in laboratory settings to induce genetic mutations in various organisms, including bacteria and mammalian cells. However, it is also classified as a hazardous substance, requiring careful handling and appropriate safety measures to mitigate exposure risks. Its use is strictly regulated in many jurisdictions due to its potential health risks, including carcinogenicity.
Formula:C2H5N5O3
InChI:InChI=1/C2H5N5O3/c1-6(7(9)10)2(3)4-5-8/h1H3,(H2,3,4,8)
InChI key:InChIKey=VZUNGTLZRAYYDE-UHFFFAOYSA-N
SMILES:C(N(N=O)C)(NN(=O)=O)=N
Synonyms:
  • 1-Methyl-1-nitroso-2-nitroguanidine
  • 1-Methyl-1-nitroso-3-nitroguanidine
  • 1-Methyl-2-Nitro-1-Nitrosoguanidine
  • 1-Methyl-3-Nitro-1-Nitroso-Guanidin
  • 1-Methyl-3-nitro-1-nitrosoguanidin
  • 1-Methyl-3-nitro-1-nitrosoguanidine
  • 1-Metil-3-Nitro-1-Nitrosoguanidina
  • 1-Nitroso-3-nitro-1-methylguanidine
  • Diazomethane precursor
  • Guanidine, 1-methyl-3-nitro-1-nitroso-
  • See more synonyms
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