CAS 700-49-2

2-Fluoroadenine

Description:

2-Fluoroadenine is a purine nucleobase derivative of adenine, characterized by the presence of a fluorine atom at the 2-position of the adenine ring. This modification can influence its biological activity and interactions with nucleic acids. The molecular formula of 2-fluoroadenine is C5H5FN5, and it has a molecular weight that reflects its composition of carbon, hydrogen, fluorine, and nitrogen atoms. The presence of the fluorine atom can enhance the stability of the compound and alter its hydrogen bonding properties, potentially affecting its role in biochemical processes. 2-Fluoroadenine is of interest in medicinal chemistry and molecular biology, particularly in the study of nucleoside analogs and their applications in antiviral and anticancer therapies. Its structural similarity to adenine allows it to participate in various biochemical pathways, although the introduction of fluorine may also lead to altered metabolic pathways. Overall, 2-fluoroadenine serves as a valuable compound for research into nucleobase modifications and their implications in biological systems.

Formula: C₅H₄FN₅

InChI: InChI=1S/C5H4FN5/c6-5-10-3(7)2-4(11-5)9-1-8-2/h1H,(H3,7,8,9,10,11)

InChI key: InChIKey=WKMPTBDYDNUJLF-UHFFFAOYSA-N

SMILES: NC1=C2C(=NC(F)=N1)N=CN2

Synonyms:

• 1H-Purin-6-amine, 2-fluoro-
• 2-Fluoro-1H-purin-6-amine
• 2-Fluoro-6-aminopurine
• 2-Fluoro-7(9)H-purin-6-ylamine
• 2-Fluoro-7H-purin-6-amine
• 2-Fluoro-9H-purin-6-amine
• 9H-Purin-6-amine, 2-fluoro-
• Adenine, 2-fluoro-
• NSC 27364

2-Fluoroadenine

CAS: 700-49-2

Formula: C₅H₄FN₅

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 153.12

Ref: 3B-F0647

2-Fluoroadenine

CAS: 700-49-2

Formula: C₅H₄FN₅

Purity: 97%

Color and Shape: Solid

Molecular weight: 153.1172

Ref: IN-DA0033BL

Fludarabine Phosphate EP Impurity D

CAS: 700-49-2

Formula: C₅H₄FN₅

Color and Shape: Off-White Solid

Molecular weight: 153.12

Ref: 4Z-F-584

2-Fluoroadenine

CAS: 700-49-2

2-Fluoroadenine

Purity: ≥98%

Molecular weight: 153.12g/mol

Ref: 54-BUP17616

2-Fluoroadenine

CAS: 700-49-2

Ref: 7W-GE1431

6-Amino-2-fluoro-9H-purine

CAS: 700-49-2

6-Amino-2-fluoro-9H-purine

Formula: C₅H₄FN₅

Purity: ≥95%

Color and Shape: white to off-white solid

Molecular weight: 153.11716g/mol

Ref: 54-PC1349

2-Fluoro-7H-purin-6-amine (2-Fluoroadenine)

CAS: 700-49-2

Color and Shape: Neat

Ref: 86-MM3428.04

2-Fluoroadenine-13C-15N3

CAS: 700-49-2

Formula: C₄₁₃CH₄FN₂₁₅N₃

Molecular weight: 157.09

Ref: 4Z-A-375002

2-Fluoroadenine

CAS: 700-49-2

2-Fluoroadenine is an inhibitor of DNA synthesis, which is used to study the effect of carcinogens on the cell cycle. It is a potent inducer of G2/M arrest in HL-60 cells, and has been shown to be cytotoxic to a number of different carcinoma cell lines. 2-Fluoroadenine disrupts collagen gel networks by binding to nitrogens in the protein matrix. This inhibits the glycosylation process that stabilizes collagen networks. The use of 2-fluoroadenine as a chemotherapeutic agent has been studied in animal models and clinical trials. 2-Fluoroadenine has been shown to inhibit mitochondrial membrane potential, leading to apoptosis caused by oxidative stress.

Formula: C₅H₄FN₅

Purity: Min. 98 Area-%

Color and Shape: Off-White Powder

Molecular weight: 153.12 g/mol

Ref: 3D-FF05946

2-Fluoroadenine

CAS: 700-49-2

Formula: C₅H₄FN₅

Purity: 85%

Color and Shape: Solid, White to off-white powder

Molecular weight: 153.12

Ref: 10-F005193

2-Fluoroadenine

Controlled Product

CAS: 700-49-2

Applications A purine nucleoside phosphorylase gene therapy for human malignancy.
References Gay, et al.: J. Bacteriol., 158, 820 (1984), Wu., et al.: J. Biol. Chem., 263, 14621 (1988), Bagshawe, et al.: J. Cancer, 60, 275 (1989), Balzarini, et al.: J. Biol. Chem., 268, 6332 (1993)

Formula: C₅H₄FN₅

Color and Shape: Neat

Molecular weight: 153.12

Ref: TR-F587200

2-Fluoroadenine

CAS: 700-49-2

2-Fluoroadenine (NSC-27364) has toxicity in nonproliferating and proliferating tumor cells. 2-Fluoroadenine can be used for anticancer studies.

Formula: C₅H₄FN₅

Purity: 98.84% - 99.62%

Color and Shape: White To Light Yellow Crystal Powder

Molecular weight: 153.12

Ref: TM-T20038

Fludarabine Phosphate EP Impurity D

CAS: 700-49-2

Formula: C₅H₄FN₅

Molecular weight: 153.12

Ref: ST-EA-CP-F71004