CAS 70030-11-4

3-Hydroxyphenazepam

Description:

3-Hydroxyphenazepam is a chemical compound belonging to the benzodiazepine class, which is known for its psychoactive properties. It is characterized by its structure, which includes a phenyl ring and a benzodiazepine core, with a hydroxyl group at the 3-position. This compound exhibits anxiolytic, sedative, and muscle relaxant effects, similar to other benzodiazepines, by modulating the activity of gamma-aminobutyric acid (GABA) receptors in the central nervous system. Its pharmacological profile suggests potential use in treating anxiety disorders and insomnia, although it may also carry risks of dependence and withdrawal. The compound is typically encountered in research settings and is not widely prescribed in clinical practice. As with many benzodiazepines, it is important to consider the legal and regulatory status of 3-Hydroxyphenazepam, as it may be classified as a controlled substance in various jurisdictions. Safety and efficacy profiles, along with potential side effects, should be thoroughly evaluated in any context of use.

Formula: C₁₅H₁₀BrClN₂O₂

InChI: InChI=1S/C15H10BrClN2O2/c16-8-5-6-12-10(7-8)13(19-15(21)14(20)18-12)9-3-1-2-4-11(9)17/h1-7,15,21H,(H,18,20)

InChI key: InChIKey=KRJKJUWAZOWXNV-UHFFFAOYSA-N

SMILES: ClC1=C(C=2C=3C(NC(=O)C(O)N2)=CC=C(Br)C3)C=CC=C1

Synonyms:

• 2H-1,4-benzodiazepin-2-one, 7-bromo-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-
• 3-Hydroxyphenazepam
• 7-Bromo-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one

3-Hydroxyphenazepam 1.0 mg/ml in Methanol

Controlled Product

CAS: 70030-11-4

Color and Shape: Single Solution

Ref: 61-AMP0828.01-01

3-Hydroxyphenazepam

Controlled Product

CAS: 70030-11-4

Color and Shape: Neat

Ref: 61-FOR0828.01

3-Hydroxyphenazepam

Controlled Product

CAS: 70030-11-4

Applications 3-Hydroxyphenazepam is a metabolite of Phenazepam (P295300), a benzodiazepine drug, which is used in the treatment of neurological disorders such as epilepsy, alcohol withdrawal and insomnia. It can be used as a premedication before surgery as it augments the effects of anesthetics and reduces anxiety.
References Ogiso, T., et al.: Chem. Pharm. Bull., 37, 446 (1989); Gu, Q., et al.: J. Med. Chem., 36, 1001 (1993); Bekhterev, V.N., et al.: Pharm. Chem. J., 42, 95 (2008)

Formula: C₁₅H₁₀BrClN₂O₂

Color and Shape: Neat

Molecular weight: 365.61

Ref: TR-H949550

3-Hydroxyphenazepam-d5

Controlled Product

CAS: 70030-11-4

Formula: C₁₅D₅H₅BrClN₂O₂

Color and Shape: Neat

Molecular weight: 370.64

Ref: TR-H949552

3-Hydroxyphenazepam (1 mg/mL in Methanol)

Controlled Product

CAS: 70030-11-4

Formula: C₁₅H₁₀BrClN₂O₂

Color and Shape: Single Solution

Molecular weight: 365.61

Ref: TR-KIT7710

3-Hydroxyphenazepam solution

Controlled Product

CAS: 70030-11-4

3-Hydroxyphenazepam is a benzodiazepine derivative that was first synthesized in the 1960s. 3-Hydroxyphenazepam is used as a premedication to relieve anxiety, as a sedative for patients with chronic or terminal illnesses, and as an anticonvulsant. It is also used in veterinary medicine. 3-Hydroxyphenazepam has been shown to be effective against gaba transporter (GAT) and has been shown to have kinetic uptake in tissues, including the brain and heart.

Formula: C₁₅H₁₀BrClN₂O₂

Purity: Min. 95%

Molecular weight: 365.61 g/mol

Ref: 3D-VCA03011