CAS 700361-47-3

Rilpivirine hydrochloride

Description:

Rilpivirine hydrochloride is an antiretroviral medication primarily used in the treatment of HIV-1 infection. It belongs to the class of non-nucleoside reverse transcriptase inhibitors (NNRTIs) and functions by inhibiting the reverse transcriptase enzyme, which is crucial for viral replication. The substance appears as a white to off-white crystalline powder and is soluble in water, making it suitable for formulation in oral dosage forms. Its chemical structure includes a pyrimidine ring, contributing to its pharmacological activity. Rilpivirine hydrochloride is typically administered once daily, often in combination with other antiretroviral agents to enhance efficacy and reduce the risk of resistance. The drug has a favorable side effect profile compared to some other antiretrovirals, with common side effects including insomnia and headache. It is essential to monitor patients for potential drug interactions, particularly with medications that induce or inhibit cytochrome P450 enzymes, as these can affect rilpivirine's metabolism and overall effectiveness.

Formula: C₂₂H₁₈N₆·ClH

InChI: InChI=1S/C22H18N6.ClH/c1-15-12-18(4-3-10-23)13-16(2)21(15)27-20-9-11-25-22(28-20)26-19-7-5-17(14-24)6-8-19;/h3-9,11-13H,1-2H3,(H2,25,26,27,28);1H/b4-3+;

InChI key: InChIKey=KZVVGZKAVZUACK-BJILWQEISA-N

SMILES: N(C1=C(C)C=C(/C=C/C#N)C=C1C)C2=NC(NC3=CC=C(C#N)C=C3)=NC=C2.Cl

Synonyms:

• Rilpivirine hydrochloride
• Benzonitrile, 4-[[4-[[4-[(1E)-2-cyanoethenyl]-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]-, monohydrochloride
• Edurant
• TMC 278 hydrochloride
• Benzonitrile, 4-[[4-[[4-[(1E)-2-cyanoethenyl]-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]-, hydrochloride (1:1)

Rilpivirine HCl

CAS: 700361-47-3

Rilpivirine HCl

Purity: ≥98%

Molecular weight: 402.88g/mol

Ref: 54-BUP09816

Rilpivirine-d6 HCl

CAS: 1312424-26-2, 700361-47-3

Formula: C₂₂H₁₂D₆N₆·HCl

Color and Shape: Off-White Solid

Molecular weight: 372.46 36.46

Ref: 4Z-R-341

Rilpivirine Hydrochloride

Controlled Product

CAS: 700361-47-3

Formula: C₂₂H₁₈N₆·ClH

Color and Shape: Neat

Molecular weight: 402.88

Ref: 86-MM3376.00

Rilpivirine HCl

CAS: 700361-47-3

Rilpivirine HCl (Rilpivirine hydrochloride) is an NNRTI inhibitor with antiviral activity that inhibits the HIV virus.

Formula: C₂₂H₁₉ClN₆

Purity: 99.48%

Color and Shape: Solid

Molecular weight: 402.88

Ref: TM-T2330L

Rilpivirine Hydrochloride

Controlled Product

CAS: 700361-47-3

Formula: C₂₂H₁₈N₆·ClH

Color and Shape: Beige

Molecular weight: 402.88

Ref: TR-R509801