CAS 70050-43-0

α-Fluoromethylhistidine

Description:

α-Fluoromethylhistidine is a synthetic analog of the amino acid histidine, characterized by the presence of a fluoromethyl group at the alpha position relative to the imidazole side chain. This modification can influence its biochemical properties and interactions. The compound is known for its potential role as a biochemical probe, particularly in studies related to enzyme activity and protein function, as it can act as a substrate or inhibitor for certain enzymes. The fluoromethyl group may enhance lipophilicity and alter the compound's reactivity compared to its non-fluorinated counterpart. α-Fluoromethylhistidine is typically utilized in research settings, particularly in the fields of biochemistry and medicinal chemistry, to investigate the mechanisms of histidine-related processes and to explore its potential therapeutic applications. As with many fluorinated compounds, it may exhibit unique pharmacokinetic properties, making it of interest in drug design and development. Safety and handling precautions should be observed, as with all chemical substances, due to potential toxicity or reactivity.

Formula: C₇H₁₀FN₃O₂

InChI: InChI=1S/C7H10FN3O2/c8-3-7(9,6(12)13)1-5-2-10-4-11-5/h2,4H,1,3,9H2,(H,10,11)(H,12,13)

InChI key: InChIKey=AJFGLTPLWPTALJ-UHFFFAOYSA-N

SMILES: C(CC1=CN=CN1)(C(O)=O)(CF)N

Synonyms:

• 2-Amino-3-fluoro-2-[(1H-imidazol-4-yl)methyl]propanoic acid
• α-Fluoromethylhistidine
• Histidine, α-(fluoromethyl)-
• α-(Fluoromethyl)histidine
• α-FMH