CAS 70052-12-9: Eflornithine

Description: Eflornithine, with the CAS number 70052-12-9, is a synthetic compound primarily used as a medication for the treatment of African sleeping sickness, specifically the second stage caused by Trypanosoma brucei gambiense. It is a reversible inhibitor of the enzyme ornithine decarboxylase, which is crucial for polyamine synthesis and cellular growth. Eflornithine is characterized by its white crystalline powder form, which is soluble in water and exhibits a relatively low molecular weight. The drug is administered intravenously and is notable for its unique mechanism of action, distinguishing it from other treatments for the disease. Eflornithine has a favorable safety profile, although it can cause side effects such as anemia and gastrointestinal disturbances. Its development marked a significant advancement in the treatment of a disease that disproportionately affects impoverished populations in sub-Saharan Africa, highlighting the importance of targeted pharmaceutical research in addressing neglected tropical diseases.

Formula: C₆H₁₂F₂N₂O₂

InChI: InChI=1S/C6H12F2N2O2/c7-4(8)6(10,5(11)12)2-1-3-9/h4H,1-3,9-10H2,(H,11,12)

InChI key: InChIKey=VLCYCQAOQCDTCN-UHFFFAOYSA-N

SMILES: O=C(O)C(N)(CCCN)C(F)F

Synonyms:

• 2,5-Diamino-2-(difluoromethyl)pentanoic acid
• 2-(Difluoromethyl)-<span class="text-smallcaps">DL</span>-ornithine
• 2-(Difluoromethyl)-Ornithin
• 2-(Difluoromethyl)Ornithine
• <span class="text-smallcaps">DL</span>-2-(Difluoromethyl)ornithine
• <span class="text-smallcaps">DL</span>-α-(Difluoromethyl)ornithine
• Alpha-Difluoromethylornithine
• Alpha-Difluromethylornithine
• D,L-2-Difluoromethylornithine
• DFMO (growth regulator)
• DL-α-Difluoromethylornithine hydrochloride
• Dfmo
• Difluoromethylornithine
• Difluromethylornithine
• Eflornithine base
• Elfornithine
• H-.alpha.-Difluoro-Me-DL-Orn-OH
• H-Dl-(A-Difluoromethyl)Orn-Oh
• Mdl 71782
• Mdl 71782A
• Ornidyl
• Ornithine, 2-(difluoromethyl)-
• Rfi 71782
• Rmi 71782
• α,δ-Diamino-α-(difluoromethyl)valeric acid
• α-(Difluoromethyl)-<span class="text-smallcaps">DL</span>-ornithine
• α-(Difluoromethyl)ornithine

Eflornithine Hydrochloride Monohydrate

CAS: 70052-12-996020-91-6

• Formula: C₆H₁₂F₂N₂O₂·HCl·H₂O
• Purity: >98.0%(T)
• Color and Shape: White to Almost white powder to crystal
• Molecular weight: 236.65

Eflornithine

CAS: 70052-12-9

• Formula: C₆H₁₂F₂N₂O₂
• Purity: 98%
• Color and Shape: Solid
• Molecular weight: 182.1685

Eflornithine

CAS: 70052-12-9

• Purity: 99%
• Molecular weight: 182.17g/mol

Eflornithine

CAS: 70052-12-9

• Formula: C₆H₁₂F₂N₂O₂
• Purity: (NMR) ≥ 98.0%
• Color and Shape: White to off-white powder
• Molecular weight: 182.17

Eflornithine

CAS: 70052-12-9

Eflornithine blocks ornithine decarboxylase, treating African trypanosomiasis and female facial hair.

• Formula: C₆H₁₂F₂N₂O₂
• Purity: 99.44%
• Color and Shape: Liquid
• Molecular weight: 182.17

DL-α-Difluoromethylornithine hydrochloride hydrate

CAS: 70052-12-9

• Formula: C₆H₁₂F₂N₂O₂·xHCl·yH₂O
• Purity: ≥ 98.0%
• Color and Shape: White solid
• Molecular weight: 182.17 (anhydrous free base)

A-Difluoromethyl-DL-ornithine

CAS: 70052-12-9

• Purity: 98.0%
• Color and Shape: Solid
• Molecular weight: 182.171

Eflornithine

CAS: 70052-12-9

Inhibitor of ornithine decarboxylase

• Formula: C₆H₁₂F₂N₂O₂
• Purity: Min. 95%
• Color and Shape: Off-White Powder
• Molecular weight: 182.17 g/mol