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CAS 70052-12-9

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Eflornithine

Description:
Eflornithine, with the CAS number 70052-12-9, is a synthetic compound primarily used as a medication for the treatment of African sleeping sickness, specifically the second stage caused by Trypanosoma brucei gambiense. It is a reversible inhibitor of the enzyme ornithine decarboxylase, which is crucial for polyamine synthesis and cellular growth. Eflornithine is characterized by its white crystalline powder form, which is soluble in water and exhibits a relatively low molecular weight. The drug is administered intravenously and is notable for its unique mechanism of action, distinguishing it from other treatments for the disease. Eflornithine has a favorable safety profile, although it can cause side effects such as anemia and gastrointestinal disturbances. Its development marked a significant advancement in the treatment of a disease that disproportionately affects impoverished populations in sub-Saharan Africa, highlighting the importance of targeted pharmaceutical research in addressing neglected tropical diseases.
Formula:C6H12F2N2O2
InChI:InChI=1/C6H12F2N2O2/c7-4(8)6(10,5(11)12)2-1-3-9/h4H,1-3,9-10H2,(H,11,12)
InChI key:InChIKey=VLCYCQAOQCDTCN-UHFFFAOYSA-N
SMILES:C(CCCN)(C(F)F)(C(O)=O)N
Synonyms:
  • 2,5-Diamino-2-(difluoromethyl)pentanoic acid
  • 2-(Difluoromethyl)-<span class="text-smallcaps">DL</span>-ornithine
  • 2-(Difluoromethyl)-Ornithin
  • 2-(Difluoromethyl)Ornithine
  • <span class="text-smallcaps">DL</span>-2-(Difluoromethyl)ornithine
  • <span class="text-smallcaps">DL</span>-α-(Difluoromethyl)ornithine
  • Alpha-Difluoromethylornithine
  • Alpha-Difluromethylornithine
  • D,L-2-Difluoromethylornithine
  • DFMO (growth regulator)
  • See more synonyms
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