CAS 700874-72-2

Galunisertib

Description:

Galunisertib, with the CAS number 700874-72-2, is a small molecule inhibitor primarily targeting the TGF-beta (transforming growth factor-beta) signaling pathway. It is classified as a selective inhibitor of the TGF-beta receptor type I (TGFBR1), which plays a crucial role in various cellular processes, including cell growth, differentiation, and immune response. Galunisertib has been investigated for its potential therapeutic applications in treating various cancers, particularly those characterized by TGF-beta overexpression, as it may help to inhibit tumor progression and metastasis. The compound is typically administered orally and has shown promise in preclinical and clinical studies, demonstrating its ability to enhance the efficacy of other cancer therapies. Its chemical structure features a unique arrangement of functional groups that contribute to its specificity and potency as a TGF-beta inhibitor. As research continues, Galunisertib's role in oncology and its potential combination with other treatments are areas of active investigation.

Formula: C₂₂H₁₉N₅O

InChI: InChI=1S/C22H19N5O/c1-13-4-2-5-18(25-13)21-20(19-6-3-11-27(19)26-21)15-9-10-24-17-8-7-14(22(23)28)12-16(15)17/h2,4-5,7-10,12H,3,6,11H2,1H3,(H2,23,28)

InChI key: InChIKey=IVRXNBXKWIJUQB-UHFFFAOYSA-N

SMILES: CC1=NC(C=2C(=C3N(N2)CCC3)C=4C5=C(C=CC(C(N)=O)=C5)N=CC4)=CC=C1

Synonyms:

• 4-[2-(6-methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl]quinoline-6-carboxamide
• 4-[5,6-Dihydro-2-(6-methyl-2-pyridinyl)-4H-pyrrolo[1,2-b]pyrazol-3-yl]-6-quinolinecarboxamide
• 6-Quinolinecarboxamide, 4-[5,6-dihydro-2-(6-methyl-2-pyridinyl)-4H-pyrrolo[1,2-b]pyrazol-3-yl]-
• Ly-2157299
• Galunisertib

4-(2-(6-methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinoline-6-carboxamide

CAS: 700874-72-2

Formula: C₂₂H₁₉N₅O

Purity: 98%

Color and Shape: Solid

Molecular weight: 369.4192

Ref: IN-DA0033SJ

Galunisertib

CAS: 700874-72-2

Galunisertib

Purity: ≥95%

Molecular weight: 369.42g/mol

Ref: 54-BUP17141

Galunisertib

CAS: 700874-72-2

Formula: C₂₂H₁₉N₅O

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 369.43

Ref: 3B-G0639

Galunisertib (LY2157299)

CAS: 700874-72-2

Formula: C₂₂H₁₉N₅O

Molecular weight: 369.43

Ref: 4Z-K-031069

Galunisertib

CAS: 700874-72-2

Galunisertib (LY2157299) is a selective TGF-β receptor type I (TGF-βRI) inhibitor. Galunisertib has antitumor activity. Cost-effective and quality-assured.

Formula: C₂₂H₁₉N₅O

Purity: 97.09% - 99.98%

Color and Shape: Solid

Molecular weight: 369.42

Ref: TM-T2510

LY2157299

CAS: 700874-72-2

LY2157299

Purity: 98%

Molecular weight: 369.42g/mol

Ref: 54-BISN0107

Galunisertib

CAS: 700874-72-2

Purity: 95.0%

Color and Shape: Solid

Molecular weight: 369.4280090332031

Ref: 10-F340506

LY2157299

CAS: 700874-72-2

Inhibitor of kinase domain of TGF-β receptor type 1

Formula: C₂₂H₁₉N₅O

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 369.42 g/mol

Ref: 3D-FM43366

LY2157299

Controlled Product

CAS: 700874-72-2

Applications LY2157299 is a TGF-β type I receptor kinase inhibitor. LY2157299 has been used to inhance chemotherapy action against triple negative breast cancer (TNBC).
References Bhola, N.E., et. al.: J. Clin. Invest., 123, 1348 (2013)

Formula: C₂₂H₁₉N₅O

Color and Shape: Neat

Molecular weight: 369.42

Ref: TR-L486320