CAS 70132-50-2

Pimonidazole

Description:

Pimonidazole is a chemical compound primarily used as a hypoxia marker in biological research and medical applications. It is a 2-nitroimidazole derivative that selectively binds to hypoxic tissues, making it valuable for studying tumor microenvironments and assessing the efficacy of cancer therapies. Pimonidazole is characterized by its ability to form stable adducts with proteins in low-oxygen conditions, which can be detected using immunohistochemical techniques. This property allows researchers to visualize and quantify hypoxic regions within tumors. The compound is typically administered intravenously and is metabolized in the body, with its binding to hypoxic cells being a key feature for its application in oncology. Additionally, Pimonidazole has been investigated for its potential role in enhancing the effectiveness of radiotherapy and chemotherapy by targeting hypoxic tumor cells. Its chemical structure includes a nitro group, which is crucial for its reactivity and binding properties. Overall, Pimonidazole serves as an important tool in cancer research, particularly in understanding tumor biology and improving treatment strategies.

Formula: C₁₁H₁₈N₄O₃

InChI: InChI=1/C11H18N4O3/c16-10(8-13-5-2-1-3-6-13)9-14-7-4-12-11(14)15(17)18/h4,7,10,16H,1-3,5-6,8-9H2

SMILES: C1CCN(CC1)CC(Cn1ccnc1N(=O)=O)O

Synonyms:

• Pimonidazole [INN:BAN]
• (+-)-alpha-((2-Nitroimidazol-1-yl)methyl)-1-piperidineethanol
• Pimonidazol
• Pimonidazol [Spanish]
• Pimonidazolum
• Pimonidazolum [Latin]
• 1-(2-nitro-1H-imidazol-1-yl)-3-(piperidin-1-yl)propan-2-ol

Pimonidazole

CAS: 70132-50-2

Formula: C₁₁H₁₈N₄O₃

Purity: 95%

Color and Shape: Solid

Molecular weight: 254.2856

Ref: IN-DA00FBIY

Pimonidazole

CAS: 70132-50-2

Formula: C₁₁H₁₈N₄O₃

Molecular weight: 254.29

Ref: 7W-GP7688

Pimonidazole hydrochloride

CAS: 70132-50-2

Formula: C₁₁H₁₈N₄O₃·HCl

Purity: ≥ 99.0%

Color and Shape: White to off-white powder

Molecular weight: 290.75

Ref: 7W-GP6511

Pimonidazole

CAS: 70132-50-2

Pimonidazole

Purity: ≥98%

Molecular weight: 254.29g/mol

Ref: 54-BUP11421

Pimonidazole

CAS: 70132-50-2

Pimonidazole, a hypoxia marker, bonds with or metabolizes in low-oxygen cells for tumor analysis.

Formula: C₁₁H₁₈N₄O₃

Purity: 99.47%

Color and Shape: Solid

Molecular weight: 254.29

Ref: TM-T16537

Pimonidazole

CAS: 70132-50-2

Purity: ≥95%

Molecular weight: 254.2899933

Ref: 10-F863713

Pimonidazole

Controlled Product

CAS: 70132-50-2

Formula: C₁₁H₁₈N₄O₃

Color and Shape: Neat

Molecular weight: 254.29

Ref: TR-P447813

Pimonidazole-d10

Controlled Product

CAS: 70132-50-2

Applications Isotope labelled Pimonidazole (P447813) is an effective and nontoxic hypoxia detection reagent. Pimonidazole forms adducts with thiol groups in proteins, peptides and amino acids. It abels hypoxic tumor cells in vivo. Also labels hypoxic mesenchymal stem cells in mouse bone marrow.
References Sato et al.: PLoS One 11 e0165946 PMID:(2016); Bennewith et al.: Cancer Res. 62 6827 PMID: 12460894, (2002);

Formula: C₁₁H₈D₁₀N₄O₃

Color and Shape: Neat

Molecular weight: 264.35

Ref: TR-P447814